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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00007239naa a2200865 4500
001oai:lup.lub.lu.se:2f67232d-cdb3-453f-88e0-fc4b043cb14b
003SwePub
008190612s2019 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/2f67232d-cdb3-453f-88e0-fc4b043cb14b2 URI
0247 a https://doi.org/10.1136/jnnp-2018-3197842 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Meeter, Lieke H.H.u Erasmus University Medical Center4 aut
2451 0a Clinical value of cerebrospinal fluid neurofilament light chain in semantic dementia
264 c 2019-05-23
264 1b BMJ,c 2019
300 a 8 s.
520 a Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FTLD subtypes, neurofilament light chain (NfL) is a promising marker, therefore we investigated the utility of cerebrospinal fluid (CSF) NfL in SD. Methods: This large retrospective multicentre study compared cross-sectional CSF NfL levels of 162 patients with SD with 65 controls. CSF NfL levels of patients were correlated with clinical parameters (including survival), neuropsychological test scores and regional grey matter atrophy (including longitudinal data in a subset). Results: CSF NfL levels were significantly higher in patients with SD (median: 2326 pg/mL, IQR: 1628-3593) than in controls (577 (446-766), p<0.001). Higher CSF NfL levels were moderately associated with naming impairment as measured by the Boston Naming Test (rs=-0.32, p=0.002) and with smaller grey matter volume of the parahippocampal gyri (rs=-0.31, p=0.004). However, cross-sectional CSF NfL levels were not associated with progression of grey matter atrophy and did not predict survival. Conclusion: CSF NfL is a promising biomarker in the diagnostic process of SD, although it has limited cross-sectional monitoring or prognostic abilities.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
7001 a Steketee, Rebecca M.E.u Erasmus University Medical Center4 aut
7001 a Salkovic, Dinau Erasmus University Medical Center4 aut
7001 a Vos, Maartje E.u Erasmus University Medical Center4 aut
7001 a Grossman, Murrayu University of Pennsylvania4 aut
7001 a McMillan, Corey T.u University of Pennsylvania4 aut
7001 a Irwin, David J.u University of Pennsylvania4 aut
7001 a Boxer, Adam L.u University of California, San Francisco4 aut
7001 a Rojas, Julio C.u University of California, San Francisco4 aut
7001 a Olney, Nicholas T.u University of California, San Francisco4 aut
7001 a Karydas, Annau University of California, San Francisco4 aut
7001 a Miller, Bruce L.u University of California, San Francisco4 aut
7001 a Pijnenburg, Yolande A.L.u Vrije Universiteit Amsterdam4 aut
7001 a Barkhof, Frederiku University College London4 aut
7001 a Sánchez-Valle, Raquelu Hospital Clínic of Barcelona4 aut
7001 a Lladó, Albertu Hospital Clínic of Barcelona4 aut
7001 a Borrego-Ecija, Sergiu Hospital Clínic of Barcelona4 aut
7001 a Diehl-Schmid, Janineu Technical University of Munich4 aut
7001 a Grimmer, Timou Technical University of Munich4 aut
7001 a Goldhardt, Oliveru Technical University of Munich4 aut
7001 a Santillo, Alexander F.u Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups4 aut0 (Swepub:lu)med-ast
7001 a Hansson, Oskaru Lund University,Lunds universitet,Neurobiologi,Forskargrupper vid Lunds universitet,Klinisk minnesforskning,LUBIN Lab- Lunds laboratorium för neurokirurgisk hjärnskadeforskning,Neurobiology,Lund University Research Groups,Clinical Memory Research,LUBIN Lab- Lund Brain Injury laboratory for Neurosurgical research4 aut0 (Swepub:lu)mphy-ohn
7001 a Vestberg, Susanneu Lund University,Lunds universitet,Psykiatri, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Institutionen för psykologi,Samhällsvetenskapliga institutioner och centrumbildningar,Samhällsvetenskapliga fakulteten,Psychiatry (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Department of Psychology,Departments of Administrative, Economic and Social Sciences,Faculty of Social Sciences4 aut0 (Swepub:lu)psyk-vsu
7001 a Borroni, Barbarau University of Brescia4 aut
7001 a Padovani, Alessandrou University of Brescia4 aut
7001 a Galimberti, Danielau University of Milan4 aut
7001 a Scarpini, Eliou University of Milan4 aut
7001 a Rohrer, Jonathan D.u University College London4 aut
7001 a Woollacott, Ione O.C.u University College London4 aut
7001 a Synofzik, Matthisu University of Tübingen,German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a Wilke, Carlou German Center for Neurodegenerative Diseases (DZNE), Bonn4 aut
7001 a De Mendonca, Alexandreu University of Lisbon4 aut
7001 a Vandenberghe, Riku University Hospitals Leuven4 aut
7001 a Benussi, Luisau Centro San Giovanni di Dio Fatebenefratelli4 aut
7001 a Ghidoni, Robertau Centro San Giovanni di Dio Fatebenefratelli4 aut
7001 a Binetti, Giulianou Centro San Giovanni di Dio Fatebenefratelli4 aut
7001 a Niessen, Wiro J.u Delft University of Technology4 aut
7001 a Papma, Janne M.u Erasmus University Medical Center4 aut
7001 a Seelaar, Harrou Erasmus University Medical Center4 aut
7001 a Jiskoot, Lize C.u Erasmus University Medical Center4 aut
7001 a De Jong, Frank Janu Erasmus University Medical Center4 aut
7001 a Donker Kaat, Laurau Erasmus University Medical Center4 aut
7001 a Del Campo, Martau Vrije Universiteit Amsterdam4 aut
7001 a Teunissen, Charlotte E.u Vrije Universiteit Amsterdam4 aut
7001 a Bron, Esther E.u Erasmus University Medical Center4 aut
7001 a Van Den Berg, Estheru Erasmus University Medical Center4 aut
7001 a Van Swieten, John C.u Erasmus University Medical Center4 aut
7102 a Erasmus University Medical Centerb University of Pennsylvania4 org
7730 t Journal of Neurology, Neurosurgery and Psychiatryd : BMJg 90:9, s. 997-1004q 90:9<997-1004x 0022-3050x 1468-330X
8564 u http://dx.doi.org/10.1136/jnnp-2018-319784x freey FULLTEXT
8564 u https://jnnp.bmj.com/content/jnnp/90/9/997.full.pdf
8564 8u https://lup.lub.lu.se/record/2f67232d-cdb3-453f-88e0-fc4b043cb14b
8564 8u https://doi.org/10.1136/jnnp-2018-319784

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