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Stem Cell-Derived H...
Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease
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- Besusso, Dario (författare)
- University of Milan
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- Schellino, Roberta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Boido, Marina (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Belloli, Sara (författare)
- San Raffaele Scientific Institute,CNR Institute of Molecular Bioimaging and Physiology, Italy (IBFM-CNR)
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- Parolisi, Roberta (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Conforti, Paola (författare)
- University of Milan
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- Faedo, Andrea (författare)
- University of Milan
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- Cernigoj, Manuel (författare)
- University of Milan
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- Campus, Ilaria (författare)
- University of Milan
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- Laporta, Angela (författare)
- University of Milan
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- Bocchi, Vittoria Dickinson (författare)
- University of Milan
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- Murtaj, Valentina (författare)
- University of Milano-Bicocca,San Raffaele Scientific Institute
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- Parmar, Malin (författare)
- Lund University,Lunds universitet,Utvecklings- och regenerativ neurobiologi,Forskargrupper vid Lunds universitet,Developmental and Regenerative Neurobiology,Lund University Research Groups
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- Spaiardi, Paolo (författare)
- University of Pavia
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- Talpo, Francesca (författare)
- University of Pavia
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- Maniezzi, Claudia (författare)
- University of Pavia
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- Toselli, Mauro Giuseppe (författare)
- University of Pavia
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- Biella, Gerardo (författare)
- University of Pavia
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- Moresco, Rosa Maria (författare)
- CNR Institute of Molecular Bioimaging and Physiology, Italy (IBFM-CNR),University of Milano-Bicocca,San Raffaele Scientific Institute
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- Vercelli, Alessandro (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Buffo, Annalisa (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Cattaneo, Elena (författare)
- University of Milan
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(creator_code:org_t)
- Elsevier BV, 2020
- 2020
- Engelska 16 s.
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Ingår i: Stem Cell Reports. - : Elsevier BV. - 2213-6711. ; 14:5, s. 876-891
- Relaterad länk:
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http://dx.doi.org/10... (free)
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http://www.cell.com/...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Huntington disease (HD) is an inherited late-onset neurological disorder characterized by progressive neuronal loss and disruption of cortical and basal ganglia circuits. Cell replacement using human embryonic stem cells may offer the opportunity to repair the damaged circuits and significantly ameliorate disease conditions. Here, we showed that in-vitro-differentiated human striatal progenitors undergo maturation and integrate into host circuits upon intra-striatal transplantation in a rat model of HD. By combining graft-specific immunohistochemistry, rabies virus-mediated synaptic tracing, and ex vivo electrophysiology, we showed that grafts can extend projections to the appropriate target structures, including the globus pallidus, the subthalamic nucleus, and the substantia nigra, and receive synaptic contact from both host and graft cells with 6.6 ± 1.6 inputs cell per transplanted neuron. We have also shown that transplants elicited a significant improvement in sensory-motor tasks up to 2 months post-transplant further supporting the therapeutic potential of this approach.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- behavioral assessment
- brain graft integration
- cell replacement therapy
- cell transplantation
- human embryonic stem cells
- Huntington disease
- medium spiny neurons
- rabies virus-based synaptic tracing
- regenerative medicine
- striatum
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Besusso, Dario
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Schellino, Rober ...
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Boido, Marina
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Belloli, Sara
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Parolisi, Robert ...
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Conforti, Paola
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visa fler...
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Faedo, Andrea
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Cernigoj, Manuel
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Campus, Ilaria
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Laporta, Angela
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Bocchi, Vittoria ...
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Murtaj, Valentin ...
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Parmar, Malin
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Spaiardi, Paolo
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Talpo, Francesca
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Maniezzi, Claudi ...
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Toselli, Mauro G ...
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Biella, Gerardo
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Moresco, Rosa Ma ...
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Vercelli, Alessa ...
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Buffo, Annalisa
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Cattaneo, Elena
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Neurovetenskaper
- Artiklar i publikationen
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Stem Cell Report ...
- Av lärosätet
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Lunds universitet