Sökning: onr:"swepub:oai:lup.lub.lu.se:34a61787-87be-4c81-8742-e546b4df2559" >
IL-33 blockade affe...
-
Allinne, JeanneRegeneron Pharmaceuticals, Inc.
(författare)
IL-33 blockade affects mediators of persistence and exacerbation in a model of chronic airway inflammation
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:34a61787-87be-4c81-8742-e546b4df2559
-
https://lup.lub.lu.se/record/34a61787-87be-4c81-8742-e546b4df2559URI
-
https://doi.org/10.1016/j.jaci.2019.08.039DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Background: Severe inflammatory airway diseases are associated with inflammation that does not resolve, leading to structural changes and an overall environment primed for exacerbations. Objective: We sought to identify and inhibit pathways that perpetuate this heightened inflammatory state because this could lead to therapies that allow for a more quiescent lung that is less predisposed to symptoms and exacerbations. Methods: Using prolonged exposure to house dust mite in mice, we developed a mouse model of persistent and exacerbating airway disease characterized by a mixed inflammatory phenotype. Results: We show that lung IL-33 drives inflammation and remodeling beyond the type 2 response classically associated with IL-33 signaling. IL-33 blockade with an IL-33 neutralizing antibody normalized established inflammation and improved remodeling of both the lung epithelium and lung parenchyma. Specifically, IL-33 blockade normalized persisting and exacerbating inflammatory end points, including eosinophilic, neutrophilic, and ST2+CD4+ T-cell infiltration. Importantly, we identified a key role for IL-33 in driving lung remodeling because anti–IL-33 also re-established the presence of ciliated cells over mucus-producing cells and decreased myofibroblast numbers, even in the context of continuous allergen exposure, resulting in improved lung function. Conclusion: Overall, this study shows that increased IL-33 levels drive a self-perpetuating amplification loop that maintains the lung in a state of lasting inflammation and remodeled tissue primed for exacerbations. Thus IL-33 blockade might ameliorate symptoms and prevent exacerbations by quelling persistent inflammation and airway remodeling.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Scott, GeorgeRegeneron Pharmaceuticals, Inc.
(författare)
-
Lim, Wei KeatRegeneron Pharmaceuticals, Inc.
(författare)
-
Birchard, DylanRegeneron Pharmaceuticals, Inc.
(författare)
-
Erjefält, Jonas S.Lund University,Lunds universitet,Luftvägsinflammation,Forskargrupper vid Lunds universitet,Airway Inflammation and Immunology,Lund University Research Groups,Medetect AB(Swepub:lu)mphy-jer
(författare)
-
Sandén, CarolineMedetect AB(Swepub:lu)mphy-cgu
(författare)
-
Ben, Li HongRegeneron Pharmaceuticals, Inc.
(författare)
-
Agrawal, AmitRegeneron Pharmaceuticals, Inc.
(författare)
-
Kaur, NavneetRegeneron Pharmaceuticals, Inc.
(författare)
-
Kim, Jee HaeRegeneron Pharmaceuticals, Inc.
(författare)
-
Kamat, VishalRegeneron Pharmaceuticals, Inc.
(författare)
-
Fury, WenRegeneron Pharmaceuticals, Inc.
(författare)
-
Huang, TammyRegeneron Pharmaceuticals, Inc.
(författare)
-
Stahl, NeilRegeneron Pharmaceuticals, Inc.
(författare)
-
Yancopoulos, George D.Regeneron Pharmaceuticals, Inc.
(författare)
-
Murphy, Andrew J.Regeneron Pharmaceuticals, Inc.
(författare)
-
Sleeman, Matthew A.Regeneron Pharmaceuticals, Inc.
(författare)
-
Orengo, Jamie M.Regeneron Pharmaceuticals, Inc.
(författare)
-
Regeneron Pharmaceuticals, Inc.Luftvägsinflammation
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:Journal of Allergy and Clinical Immunology: Elsevier BV144:6, s. 1624-16370091-6749
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Allinne, Jeanne
-
Scott, George
-
Lim, Wei Keat
-
Birchard, Dylan
-
Erjefält, Jonas ...
-
Sandén, Caroline
-
visa fler...
-
Ben, Li Hong
-
Agrawal, Amit
-
Kaur, Navneet
-
Kim, Jee Hae
-
Kamat, Vishal
-
Fury, Wen
-
Huang, Tammy
-
Stahl, Neil
-
Yancopoulos, Geo ...
-
Murphy, Andrew J ...
-
Sleeman, Matthew ...
-
Orengo, Jamie M.
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Lungmedicin och ...
- Artiklar i publikationen
-
Journal of Aller ...
- Av lärosätet
-
Lunds universitet