Search: onr:"swepub:oai:lup.lub.lu.se:3d4c18e7-5f32-4cef-9bdf-e6263d8a7cc4" >
Second malignancies...
Second malignancies following treatment of chronic myeloid leukaemia in the tyrosine kinase inhibitor era
-
- Gunnarsson, Niklas (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
-
- Stenke, Leif (author)
- Karolinska Institutet
-
- Höglund, Martin (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden; University of Uppsala Hospital, Sweden
-
show more...
-
- Sandin, Fredrik (author)
- Regional Cancer Centre, Sweden
-
- Bjorkholm, Magnus (author)
- Karolinska Institutet
-
- Dreimane, Arta (author)
- Linköpings universitet,Institutionen för medicin och hälsa,Medicinska fakulteten,Region Östergötland, Hematologiska kliniken US
-
- Lambe, Mats (author)
- Karolinska Institutet
-
- Markevärn, Berit (author)
- Department of Haematology, University Hospital, Umeå,Umeå University Hospital, Sweden
-
- Olsson-Strömberg, Ulla (author)
- Uppsala universitet,Hematologi,University of Uppsala Hospital, Sweden; University of Uppsala Hospital, Sweden
-
- Richter, Johan (author)
- Lund University,Lunds universitet,Avdelningen för molekylärmedicin och genterapi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Molecular Medicine and Gene Therapy,Department of Laboratory Medicine,Faculty of Medicine,Skåne University Hospital, Sweden
-
- Wadenvik, Hans (author)
- Sahlgrens University Hospital, Sweden
-
- Wallvik, Jonas (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
-
- Själander, Anders (author)
- Umeå universitet,Medicin,Sundsvall Research Unit, Umeå University,Umeå University, Sweden
-
show less...
-
(creator_code:org_t)
- 2015-03-27
- 2015
- English.
-
In: British Journal of Haematology. - : Wiley. - 0007-1048 .- 1365-2141. ; 169:5, s. 683-688
- Related links:
-
http://dx.doi.org/10...
-
show more...
-
https://onlinelibrar...
-
https://lup.lub.lu.s...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
https://urn.kb.se/re...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Given that tyrosine kinase inhibitors (TKIs) have dramatically improved the survival of patients with chronic myeloid leukaemia (CML), we were interested in examining the possible risk of long-term adverse events, such as the emergence of other neoplasms. Therefore, we studied the development of second malignancies in 868 patients diagnosed with CML between 2002 and 2011 using the Swedish CML register, cross-linked to the Swedish Cancer register. With a median follow-up of 37 (range 0-99)years, 65 (75%) patients developed 75 second malignancies (non-haematological), 52 of which were of the invasive type. Compared to expected rates in the background population, the risk of second malignancies was higher in the CML cohort, with a standardized incidence ratio (SIR) of 152 (95% CI 113-199). The SIR before and after the second year following diagnosis of CML was 158 and 147, respectively. Among specific cancer types, gastrointestinal and nose and throat cancer were significantly increased. Founded on a population-based material, our results indicate that CML patients treated in the TKI era are at an increased risk of developing a second malignancy, with indications that this risk may more likely be linked to CML itself rather than to the TKI treatment.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- chronic myeloid leukaemia
- treatment
- malignancy
- chronic myeloid leukaemia
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
-
Gunnarsson, Nikl ...
-
Stenke, Leif
-
Höglund, Martin
-
Sandin, Fredrik
-
Bjorkholm, Magnu ...
-
Dreimane, Arta
-
show more...
-
Lambe, Mats
-
Markevärn, Berit
-
Olsson-Strömberg ...
-
Richter, Johan
-
Wadenvik, Hans
-
Wallvik, Jonas
-
Själander, Ander ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Cancer and Oncol ...
- Articles in the publication
-
British Journal ...
- By the university
-
Lund University
-
Uppsala University
-
Umeå University
-
Linköping University
-
Karolinska Institutet