Sökning: onr:"swepub:oai:lup.lub.lu.se:3d812759-1784-441f-9e44-605fa0ee35bf" > Trans-omics biomark...
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000 | 05311naa a2200673 4500 | |
001 | oai:lup.lub.lu.se:3d812759-1784-441f-9e44-605fa0ee35bf | |
003 | SwePub | |
008 | 190918s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/3d812759-1784-441f-9e44-605fa0ee35bf2 URI |
024 | 7 | a https://doi.org/10.18632/aging.1021892 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Dong, Xuesiu Nanjing Medical University,Southeast University4 aut |
245 | 1 0 | a Trans-omics biomarker model improves prognostic prediction accuracy for early-stage lung adenocarcinoma |
264 | c 2019-08-21 | |
264 | 1 | b Impact Journals, LLC,c 2019 |
300 | a 24 s. | |
520 | a Limited studies have focused on developing prognostic models with trans-omics biomarkers for early-stage lung adenocarcinoma (LUAD). We performed integrative analysis of clinical information, DNA methylation, and gene expression data using 825 early-stage LUAD patients from 5 cohorts. Ranger algorithm was used to screen prognosis-associated biomarkers, which were confirmed with a validation phase. Clinical and biomarker information was fused using an iCluster plus algorithm, which significantly distinguished patients into high- and low-mortality risk groups (Pdiscovery = 0.01 and Pvalidation = 2.71×10-3). Further, potential functional DNA methylation-gene expression-overall survival pathways were evaluated by causal mediation analysis. The effect of DNA methylation level on LUAD survival was significantly mediated through gene expression level. By adding DNA methylation and gene expression biomarkers to a model of only clinical data, the AUCs of the trans-omics model improved by 18.3% (to 87.2%) and 16.4% (to 85.3%) in discovery and validation phases, respectively. Further, concordance index of the nomogram was 0.81 and 0.77 in discovery and validation phases, respectively. Based on systematic review of published literatures, our model was superior to all existing models for early-stage LUAD. In summary, our trans-omics model may help physicians accurately identify patients with high mortality risk. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
653 | a DNA methylation | |
653 | a early-stage | |
653 | a gene expression | |
653 | a lung adenocarcinoma | |
653 | a prognostic prediction | |
700 | 1 | a Zhang, Ruyangu Harvard University,Nanjing Medical University,Nanjing University4 aut |
700 | 1 | a He, Jieyuu Nanjing Medical University4 aut |
700 | 1 | a Lai, Linjingu Nanjing Medical University4 aut |
700 | 1 | a Alolga, Raphael N.u China Pharmaceutical University4 aut |
700 | 1 | a Shen, Sipengu Nanjing Medical University,Harvard University4 aut |
700 | 1 | a Zhu, Yingu Nanjing Medical University4 aut |
700 | 1 | a You, Dongfangu Nanjing Medical University4 aut |
700 | 1 | a Lin, Lijuanu Nanjing Medical University4 aut |
700 | 1 | a Chen, Chaou Nanjing Medical University4 aut |
700 | 1 | a Zhao, Yangu Nanjing Medical University4 aut |
700 | 1 | a Duan, Weiweiu Nanjing Medical University4 aut |
700 | 1 | a Su, Liu Nanjing Medical University,Harvard University4 aut |
700 | 1 | a Shafer, Andreau Massachusetts General Hospital,Harvard University4 aut |
700 | 1 | a Salama, Moranu Bellvitge Biomedical Research Institute,University of Barcelona4 aut |
700 | 1 | a Fleischer, Thomasu Oslo university hospital4 aut |
700 | 1 | a Bjaanæs, Maria Moksnesu Oslo university hospital4 aut |
700 | 1 | a Karlsson, Annau Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups4 aut0 (Swepub:lu)med-akn |
700 | 1 | a Planck, Mariau Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups4 aut0 (Swepub:lu)onk-mpl |
700 | 1 | a Wang, Ruiu Nanjing University4 aut |
700 | 1 | a Staaf, Johanu Lund University,Lunds universitet,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,Research Group Lung Cancer,Lund University Research Groups4 aut0 (Swepub:lu)onk-jst |
700 | 1 | a Helland, Åslaugu Oslo university hospital,University of Oslo4 aut |
700 | 1 | a Esteller, Manelu Bellvitge Biomedical Research Institute,University of Barcelona4 aut |
700 | 1 | a Wei, Yongyueu Nanjing Medical University,Harvard University4 aut |
700 | 1 | a Chen, Fengu Nanjing Medical University,Southeast University4 aut |
700 | 1 | a Christiani, David C.u Harvard University,Massachusetts General Hospital,Nanjing Medical University4 aut |
710 | 2 | a Nanjing Medical Universityb Southeast University4 org |
773 | 0 | t Agingd : Impact Journals, LLCg 11:16, s. 6312-6335q 11:16<6312-6335x 1945-4589 |
856 | 4 | u http://dx.doi.org/10.18632/aging.102189x freey FULLTEXT |
856 | 4 | u https://doi.org/10.18632/aging.102189 |
856 | 4 8 | u https://lup.lub.lu.se/record/3d812759-1784-441f-9e44-605fa0ee35bf |
856 | 4 8 | u https://doi.org/10.18632/aging.102189 |
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