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Low vitamin d levels and frailty status in older adults : A systematic review and meta-analysis
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- Marcos-Pérez, Diego (author)
- University of A Coruña,Institute of Biomedical Research of A Coruña, INIBIC
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- Sánchez-Flores, María (author)
- National Health Institute Doutor Ricardo Jorge, Lisbon,University of A Coruña,University of Porto
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- Proietti, Stefania (author)
- IRCCS San Raffaele Pisana
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- (creator_code:org_t)
- 2020-07-30
- 2020
- English 20 s.
- In: Nutrients. - : MDPI AG. - 2072-6643. ; 12:8
- Research review (peer-reviewed)
Abstract
Subject headings
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- Serum vitamin D deficiency is widespread among older adults and is a potential modifiable risk factor for frailty. Moreover, frailty has been suggested as an intermediate step in the association between low levels of vitamin D and mortality. Hence, we conducted a systematic review of the literature and meta-analysis to test the possible association of low concentrations of serum 25-hydroxyvitamin D (25(OH)D), a marker of vitamin D status, with frailty in later life. We reviewed cross-sectional or longitudinal studies evaluating populations of older adults and identifying frailty by a currently validated scale. Meta-analyses were restricted to cross-sectional data from studies using Fried’s phenotype to identify frailty. Twenty-six studies were considered in the qualitative synthesis, and thirteen studies were included in the meta-analyses. Quantitative analyses showed significant differences in the comparisons of frail (standardized mean difference (SMD)—1.31, 95% confidence interval (CI) (−2.47, −0.15), p = 0.0271) and pre-frail (SMD—0.79, 95% CI (−1.58, −0.003), p = 0.0491) subjects vs. non-frail subjects. Sensitivity analyses reduced heterogeneity, resulting in a smaller but still highly significant between-groups difference. Results obtained indicate that lower 25(OH)D levels are significantly associated with increasing frailty severity. Future challenges include interventional studies testing the possible benefits of vitamin D supplementation in older adults to prevent/palliate frailty and its associated outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Keyword
- Frailty
- Meta-analysis
- Older adults
- Systematic review
- Vitamin D
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