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Anti-tumor effects ...
Anti-tumor effects of PIM/PI3K/mTOR triple kinase inhibitor IBL-302 in neuroblastoma
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- Mohlin, Sofie (författare)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups
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- Hansson, Karin (författare)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
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- Radke, Katarzyna (författare)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
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- Martinez, Sonia (författare)
- Spanish National Cancer Research Center (CNIO)
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- Blanco-Apiricio, Carmen (författare)
- Spanish National Cancer Research Center (CNIO)
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- Garcia-Ruiz, Cristian (författare)
- Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine
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- Welinder, Charlotte (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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- Esfandyari, Javanshir (författare)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
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- O'Neill, Michael (författare)
- Inflection Biosciences Ltd
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- Pastor, Joaquin (författare)
- Spanish National Cancer Research Center (CNIO)
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- von Stedingk, Kristoffer (författare)
- Lund University,Lunds universitet,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,Lund University Research Groups,Academic Medical Center of University of Amsterdam (AMC)
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- Bexell, Daniel (författare)
- Lund University,Lunds universitet,Molekylär barnonkologi,Forskargrupper vid Lunds universitet,Molecular Pediatric Oncology,Lund University Research Groups
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(creator_code:org_t)
- 2019-07-16
- 2019
- Engelska.
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Ingår i: EMBO Molecular Medicine. - : EMBO. - 1757-4676 .- 1757-4684. ; 11:8
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://onlinelibrar...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The PI3K pathway is a major driver of cancer progression. However, clinical resistance to PI3K inhibition is common. IBL-302 is a novel highly specific triple PIM, PI3K, and mTOR inhibitor. Screening IBL-302 in over 700 cell lines representing 47 tumor types identified neuroblastoma as a strong candidate for PIM/PI3K/mTOR inhibition. IBL-302 was more effective than single PI3K inhibition in vitro, and IBL-302 treatment of neuroblastoma patient-derived xenograft (PDX) cells induced apoptosis, differentiated tumor cells, and decreased N-Myc protein levels. IBL-302 further enhanced the effect of the common cytotoxic chemotherapies cisplatin, doxorubicin, and etoposide. Global genome, proteome, and phospho-proteome analyses identified crucial biological processes, including cell motility and apoptosis, targeted by IBL-302 treatment. While IBL-302 treatment alone reduced tumor growth in vivo, combination therapy with low-dose cisplatin inhibited neuroblastoma PDX growth. Complementing conventional chemotherapy treatment with PIM/PI3K/mTOR inhibition has the potential to improve clinical outcomes and reduce severe late effects in children with high-risk neuroblastoma.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Nyckelord
- cisplatin
- IBL-302
- multikinase inhibition
- neuroblastoma
- PI3K
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Mohlin, Sofie
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Hansson, Karin
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Radke, Katarzyna
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Martinez, Sonia
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Blanco-Apiricio, ...
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Garcia-Ruiz, Cri ...
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visa fler...
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Welinder, Charlo ...
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Esfandyari, Java ...
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O'Neill, Michael
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Pastor, Joaquin
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von Stedingk, Kr ...
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Bexell, Daniel
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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EMBO Molecular M ...
- Av lärosätet
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Lunds universitet