Sökning: onr:"swepub:oai:lup.lub.lu.se:4ae15766-1d41-4126-90cf-ddfee80e3cfa" > Genetic variation i...
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000 | 05316naa a2200565 4500 | |
001 | oai:lup.lub.lu.se:4ae15766-1d41-4126-90cf-ddfee80e3cfa | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:132481081 | |
024 | 7 | a https://lup.lub.lu.se/record/81491442 URI |
024 | 7 | a https://doi.org/10.1016/j.plefa.2015.08.0042 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1324810812 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a for2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Yeates, Alison J4 aut |
245 | 1 0 | a Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study. |
264 | 1 | b Elsevier BV,c 2015 |
338 | a electronic2 rdacarrier | |
520 | a Long-chain n-6 and n-3 PUFA (LC-PUFA), arachidonic acid (AA) (20:4n-6) and DHA (22:6n-3), are critical for optimal brain development. These fatty acids can be consumed directly from the diet, or synthesized endogenously from precursor PUFA by Δ-5 (encoded by FADS1) and Δ-6 desaturases (encoded by FADS2). The aim of this study was to determine the potential importance of maternal genetic variability in FADS1 and FADS2 genes to maternal LC-PUFA status and infant neurodevelopment in populations with high fish intakes. The Nutrition Cohorts 1 (NC1) and 2 (NC2) are longitudinal observational mother-child cohorts in the Republic of Seychelles. Maternal serum LC-PUFA was measured at 28 weeks gestation and genotyping for rs174537 (FADS1), rs174561 (FADS1), rs3834458 (FADS1-FADS2) and rs174575 (FADS2) was performed in both cohorts. The children completed the Bayley Scales of Infant Development II (BSID-II) at 30 months in NC1 and at 20 months in NC2. Complete data were available for 221 and 1310 mothers from NC1 and NC2 respectively. With increasing number of rs3834458 minor alleles, maternal concentrations of AA were significantly decreased (NC1 p=0.004; NC2 p<0.001) and precursor:product ratios for linoleic acid (LA) (18:2n-6)-to-AA (NC1 p<0.001; NC2 p<0.001) and α-linolenic acid (ALA) (18:3n-3)-to-DHA were increased (NC2 p=0.028). There were no significant associations between maternal FADS genotype and BSID-II scores in either cohort. A trend for improved PDI was found among infants born to mothers with the minor rs3834458 allele.In these high fish-eating cohorts, genetic variability in FADS genes was associated with maternal AA status measured in serum and a subtle association of the FADS genotype was found with neurodevelopment. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Arbetsmedicin och miljömedicin0 (SwePub)303032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Occupational Health and Environmental Health0 (SwePub)303032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
700 | 1 | a Love, Tanzy M4 aut |
700 | 1 | a Engström, Karinu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-ksk |
700 | 1 | a Mulhern, Maria S4 aut |
700 | 1 | a McSorley, Emeir M4 aut |
700 | 1 | a Grzesik, Katherine4 aut |
700 | 1 | a Alhamdow, Aymanu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)med-aa10 |
700 | 1 | a Wahlberg, Karin Eu Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine4 aut0 (Swepub:lu)immu-kwa |
700 | 1 | a Thurston, Sally W4 aut |
700 | 1 | a Davidson, Philip W4 aut |
700 | 1 | a van Wijngaarden, Edwin4 aut |
700 | 1 | a Watson, Gene E4 aut |
700 | 1 | a Shamlaye, Conrad F4 aut |
700 | 1 | a Myers, G J4 aut |
700 | 1 | a Strain, J J4 aut |
700 | 1 | a Broberg, Karin4 aut |
710 | 2 | a Avdelningen för arbets- och miljömedicinb Institutionen för laboratoriemedicin4 org |
773 | 0 | t Prostaglandins, Leukotrienes and Essential Fatty Acidsd : Elsevier BVg 102-103, s. 13-20q 102-103<13-20x 0952-3278x 1532-2823 |
856 | 4 | u https://portal.research.lu.se/files/1564237/8862712.pdfx primaryx freey FULLTEXT |
856 | 4 | u http://www.ncbi.nlm.nih.gov/pubmed/26474818?dopt=Abstractx freey FULLTEXT |
856 | 4 | u http://dx.doi.org/10.1016/j.plefa.2015.08.004x freey FULLTEXT |
856 | 4 | u http://www.plefa.com/article/S0952327815001556/pdf |
856 | 4 8 | u https://lup.lub.lu.se/record/8149144 |
856 | 4 8 | u https://doi.org/10.1016/j.plefa.2015.08.004 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:132481081 |
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