onr:"swepub:oai:lup.lub.lu.se:5257028c-e168-443e-a6ea-21fde282e043"
Search: onr:"swepub:oai:lup.lub.lu.se:5257028c-e168-443e-a6ea-21fde282e043" > Efficacy assessment...
- 1 of 1
- Previous record
- Next record
- To hitlist
- Cullen, Nicholas C.Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups (author)
Efficacy assessment of an active tau immunotherapy in Alzheimer's disease patients with amyloid and tau pathology : a post hoc analysis of the “ADAMANT” randomised, placebo-controlled, double-blind, multi-centre, phase 2 clinical trial
- Article/chapterEnglish2024
Publisher, publication year, extent ...
- 2024
Numbers
- LIBRIS-ID:oai:lup.lub.lu.se:5257028c-e168-443e-a6ea-21fde282e043
- https://lup.lub.lu.se/record/5257028c-e168-443e-a6ea-21fde282e043URI
- https://doi.org/10.1016/j.ebiom.2023.104923DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:154606349URI
Supplementary language notes
- Language:English
- Summary in:English
Part of subdatabase
- SwePubSwePub
Classification
Notes
- Background: Tau pathology correlates with and predicts clinical decline in Alzheimer's disease. Approved tau-targeted therapies are not available. Methods: ADAMANT, a 24-month randomised, placebo-controlled, parallel-group, double-blinded, multicenter, Phase 2 clinical trial (EudraCT2015-000630-30, NCT02579252) enrolled 196 participants with Alzheimer's disease; 119 are included in this post-hoc subgroup analysis. AADvac1, active immunotherapy against pathological tau protein. A machine learning model predicted likely Amyloid+Tau+ participants from baseline MRI. Statistical methods: MMRM for change from baseline in cognition, function, and neurodegeneration; linear regression for associations between antibody response and endpoints. Results: The prediction model achieved PPV of 97.7% for amyloid, 96.2% for tau. 119 participants in the full analysis set (70 treatment and 49 placebo) were classified as A+T+. A trend for CDR-SB 104-week change (estimated marginal means [emm] = −0.99 points, 95% CI [−2.13, 0.13], p = 0.0825]) and ADCS-MCI-ADL (emm = 3.82 points, CI [−0.29, 7.92], p = 0.0679) in favour of the treatment group was seen. Reduction was seen in plasma NF-L (emm = −0.15 log pg/mL, CI [−0.27, −0.03], p = 0.0139). Higher antibody response to AADvac1 was related to slowing of decline on CDR-SB (rho = −0.10, CI [−0.21, 0.01], p = 0.0376) and ADL (rho = 0.15, CI [0.03, 0.27], p = 0.0201), and related to slower brain atrophy (rho = 0.18–0.35, p < 0.05 for temporal volume, whole cortex, and right and left hippocampus). Conclusions: In the subgroup of ML imputed or CSF identified A+T+, AADvac1 slowed AD-related decline in an antibody-dependent manner. Larger anti-tau trials are warranted. Funding: AXON Neuroscience SE.
Subject headings and genre
- MEDICIN OCH HÄLSOVETENSKAP Medicinska och farmaceutiska grundvetenskaper Neurovetenskaper hsv//swe
- MEDICAL AND HEALTH SCIENCES Basic Medicine Neurosciences hsv//eng
- Alzheimer's disease
- Immunotherapy
- Machine learning
- Post-hoc analysis
- Tau
Added entries (persons, corporate bodies, meetings, titles ...)
- Novak, PetrAxon Neuroscience SE (author)
- Tosun, DuyguSan Francisco Veterans Administration Medical Center,University of California, San Francisco (author)
- Kovacech, BranislavAxon Neuroscience SE (author)
- Hanes, Jozef (author)
- Kontsekova, Eva (author)
- Fresser, MichalAxon Neuroscience SE (author)
- Ropele, StefanMedical University of Graz (author)
- Feldman, Howard H. (author)
- Schmidt, ReinholdMedical University of Graz (author)
- Winblad, BengtKarolinska Institutet,Karolinska University Hospital (author)
- Zilka, NorbertAxon Neuroscience SE (author)
- Klinisk minnesforskningForskargrupper vid Lunds universitet (creator_code:org_t)
Related titles
- In:EBioMedicine992352-3964
Internet link
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Cullen, Nicholas ...
- Novak, Petr
- Tosun, Duygu
- Kovacech, Branis ...
- Hanes, Jozef
- Kontsekova, Eva
- show more...
- Fresser, Michal
- Ropele, Stefan
- Feldman, Howard ...
- Schmidt, Reinhol ...
- Winblad, Bengt
- Zilka, Norbert
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Basic Medicine
- and Neurosciences
- Articles in the publication
- EBioMedicine
- By the university
- Lund University
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
