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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04089naa a2200469 4500 | |
| 001 | oai:lup.lub.lu.se:555d1f82-97b0-4720-a6cd-49b3e10a50a8 | |
| 003 | SwePub | |
| 008 | 221205s2022 | |||||||||||000 ||eng| | |
| 009 | oai:DiVA.org:mau-66844 | |
| 024 | 7 | a https://lup.lub.lu.se/record/555d1f82-97b0-4720-a6cd-49b3e10a50a82 URI |
| 024 | 7 | a https://doi.org/10.1002/1873-3468.144902 DOI |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-668442 URI |
| 040 | a (SwePub)lud (SwePub)mau | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Petrlova, Jitkau Lund University,Lunds universitet,Dermatologi och venereologi, Lund,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Schmidtchen lab,Forskargrupper vid Lunds universitet,Dermatology and Venereology (Lund),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Schmidtchen Lab,Lund University Research Groups,Division of Dermatology and Venereology, Department of Clinical Sciences Lund University Sweden4 aut0 (Swepub:mau)ap8809 |
| 245 | 1 0 | a SARS-CoV-2 spike protein aggregation is triggered by bacterial lipopolysaccharide |
| 264 | c 2022-09-11 | |
| 264 | 1 | b Wiley,c 2022 |
| 300 | a 10 s. | |
| 520 | a SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thioflavin T dyes that specifically bind to aggregating proteins. We validated the role of LPS by blocking the formation of aggregates by the endotoxin-scavenging thrombin-derived peptide TCP-25. Aggregation-prone sequences in S protein are predicted to be nearby LPS binding sites, while molecular simulations showed stable formation of S protein–LPS higher-order oligomers. Collectively, our results provide evidence of LPS-induced S protein aggregation. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
| 653 | a COVID-19 | |
| 653 | a endotoxins | |
| 653 | a inflammation | |
| 653 | a lipopolysaccharide | |
| 653 | a protein-aggregation | |
| 653 | a spike protein | |
| 700 | 1 | a Samsudin, Firdausu Bioinformatics Institute (BII) Agency for Science, Technology and Research (A*STAR) Singapore City Singapore4 aut |
| 700 | 1 | a Bond, Peter J.u Bioinformatics Institute (BII) Agency for Science, Technology and Research (A*STAR) Singapore City Singapore;Department of Biological Sciences National University of Singapore Singapore,National University of Singapore4 aut |
| 700 | 1 | a Schmidtchen, Arturu Lund University,Lunds universitet,Schmidtchen lab,Forskargrupper vid Lunds universitet,Schmidtchen Lab,Lund University Research Groups,Division of Dermatology and Venereology, Department of Clinical Sciences Lund University Sweden;Department of Biomedical Sciences, Copenhagen Wound Healing Center, Bispebjerg Hospital University of Copenhagen Denmark;Dermatology Skåne University Hospital Lund Sweden,Skåne University Hospital4 aut0 (Swepub:lu)derm-asc |
| 710 | 2 | a Dermatologi och venereologi, Lundb Sektion III4 org |
| 773 | 0 | t FEBS Lettersd : Wileyg 596:19, s. 2566-2575q 596:19<2566-2575x 0014-5793x 1873-3468 |
| 856 | 4 | u http://dx.doi.org/10.1002/1873-3468.14490x freey FULLTEXT |
| 856 | 4 | u https://doi.org/10.1002/1873-3468.14490y Fulltext |
| 856 | 4 | u https://mau.diva-portal.org/smash/get/diva2:1853458/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 8 | u https://lup.lub.lu.se/record/555d1f82-97b0-4720-a6cd-49b3e10a50a8 |
| 856 | 4 8 | u https://doi.org/10.1002/1873-3468.14490 |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-66844 |
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