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Prenatal Mancozeb E...
Prenatal Mancozeb Exposure, Excess Manganese, and Neurodevelopment at 1 Year of Age in the Infants' Environmental Health (ISA) Study
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- Mora, Ana María (författare)
- National University Of Costa Rica,University of California, Berkeley
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- Córdoba, Leonel (författare)
- National University Of Costa Rica
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- Cano, Juan Camilo (författare)
- National University Of Costa Rica
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- Hernandez-Bonilla, David (författare)
- National Institute of Public Health, Mexico
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- Pardo, Larissa (författare)
- National University Of Costa Rica
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- Schnaas, Lourdes (författare)
- National Institute Of Perinatology (INPer)
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- Smith, Donald R. (författare)
- University of California, Santa Cruz
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- Menezes-Filho, José A. (författare)
- Federal University of Bahia
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- Mergler, Donna (författare)
- University Of Quebec In Montreal
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- Lindh, Christian H. (författare)
- Lund University,Lunds universitet,Avdelningen för arbets- och miljömedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Tillämpad masspektrometri inom miljömedicin,Forskargrupper vid Lunds universitet,Division of Occupational and Environmental Medicine, Lund University,Department of Laboratory Medicine,Faculty of Medicine,Applied Mass Spectrometry in Environmental Medicine,Lund University Research Groups
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- Eskenazi, Brenda (författare)
- University of California, Berkeley
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- van Wendel de Joode, Berna (författare)
- National University Of Costa Rica
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(creator_code:org_t)
- 2018
- 2018
- Engelska.
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Ingår i: Environmental Health Perspectives. - 1552-9924. ; 126:5
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
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- BACKGROUND: Although growing evidence suggests that early-life excess manganese (Mn) impairs neurodevelopment, data on the neurodevelopmental effects of mancozeb, a fungicide containing Mn, and its main metabolite ethylenethiourea (ETU) are limited. OBJECTIVE: We examined whether prenatal mancozeb exposure and excess Mn were associated with neurodevelopment in 355 1-y-old infants living near banana plantations with frequent aerial mancozeb spraying in Costa Rica. METHODS: We measured urinary ETU, hair Mn, and blood Mn concentrations in samples collected 1-3 times during pregnancy from mothers enrolled in the Infants' Environmental Health (ISA) study. We then assessed neurodevelopment in their 1-y-old infants using the Bayley Scales of Infant and Toddler Development, 3rd edition (BSID-III). We estimated exposure-outcome associations using linear regression models adjusted for maternal education, parity, gestational age at birth, child age, Home Observation for Measurement of the Environment score, and location of neurodevelopmental assessment. RESULTS: Median (P25-P75) urinary ETU, hair Mn, and blood Mn measured during pregnancy were 3.3 μg/L (2.4-4.9; specific gravity-corrected), 1.7 μg/g (0.9-4.1), and 24.0 μg/L (20.3-28.0), respectively. Among girls, higher ETU was associated with lower social-emotional scores [β per 10-fold increase=-7.4 points (95% CI: -15.2, 0.4)], whereas higher hair Mn was associated with lower cognitive scores [-3.0 (-6.1, 0.1)]. Among boys, higher hair Mn was associated with lower social-emotional scores [-4.6 (-8.5, -0.8)]. We observed null associations for blood Mn, language, and motor outcomes. CONCLUSIONS: Our findings indicate that maternal exposure to mancozeb and excess Mn during pregnancy may have adverse and sex-specific effects on infant neurodevelopment. https://doi.org/10.1289/EHP1955.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Pediatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Pediatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
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Mora, Ana María
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Córdoba, Leonel
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Cano, Juan Camil ...
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Hernandez-Bonill ...
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Pardo, Larissa
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Schnaas, Lourdes
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visa fler...
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Smith, Donald R.
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Menezes-Filho, J ...
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Mergler, Donna
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Lindh, Christian ...
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Eskenazi, Brenda
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van Wendel de Jo ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Pediatrik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Arbetsmedicin oc ...
- Artiklar i publikationen
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Environmental He ...
- Av lärosätet
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Lunds universitet