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Lipid-associated ma...
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications
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- Dib, Lea (författare)
- University of Oxford
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- Koneva, Lada A. (författare)
- University of Oxford
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- Edsfeldt, Andreas (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Zurke, Yasemin Xiomara (författare)
- University of Oxford
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- Sun, Jiangming (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups
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- Nitulescu, Mihaela (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups
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- Attar, Moustafa (författare)
- University of Oxford
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- Lutgens, Esther (författare)
- Mayo Clinic Minnesota
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- Schmidt, Steffen (författare)
- Roche Innovation Center Copenhagen
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- Lindholm, Marie W. (författare)
- Roche Innovation Center Copenhagen
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- Choudhury, Robin P. (författare)
- University of Oxford
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- Cassimjee, Ismail (författare)
- University of Oxford
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- Lee, Regent (författare)
- University of Oxford
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- Handa, Ashok (författare)
- University of Oxford
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- Goncalves, Isabel (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital
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- Sansom, Stephen N. (författare)
- University of Oxford
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- Monaco, Claudia (författare)
- University of Oxford
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(creator_code:org_t)
- 2023
- 2023
- Engelska.
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Ingår i: Nature Cardiovascular Research. - 2731-0590. ; 2:7, s. 656-672
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in which macrophages play a nonredundant role. However, evidence emerging so far from single-cell atlases suggests a dichotomy between lipid-associated and inflammatory macrophage states. Here, we present an inclusive reference atlas of human intraplaque immune cell communities. Combining single-cell RNA sequencing (scRNA-seq) of human surgical carotid endarterectomies in a discovery cohort with bulk RNA-seq and immunohistochemistry in a validation cohort (the Carotid Plaque Imaging Project), we reveal the existence of PLIN2hi/TREM1hi macrophages as a Toll-like receptor (TLR)-dependent inflammatory lipid-associated macrophage state linked to cerebrovascular events. Our study shifts the current paradigm of lipid-driven inflammation by providing biological evidence for a pathogenic macrophage transition to an inflammatory lipid-associated phenotype and for its targeting as a new treatment strategy for cardiovascular disease.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Dib, Lea
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Koneva, Lada A.
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Edsfeldt, Andrea ...
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Zurke, Yasemin X ...
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Sun, Jiangming
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Nitulescu, Mihae ...
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visa fler...
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Attar, Moustafa
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Lutgens, Esther
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Schmidt, Steffen
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Lindholm, Marie ...
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Choudhury, Robin ...
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Cassimjee, Ismai ...
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Lee, Regent
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Handa, Ashok
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Goncalves, Isabe ...
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Sansom, Stephen ...
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Monaco, Claudia
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Nature Cardiovas ...
- Av lärosätet
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Lunds universitet