Search: onr:"swepub:oai:lup.lub.lu.se:5e115992-c042-4cad-a118-6c77a4769730" >
Lipid-associated ma...
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Dib, LeaUniversity of Oxford
(author)
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications
- Article/chapterEnglish2023
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LIBRIS-ID:oai:lup.lub.lu.se:5e115992-c042-4cad-a118-6c77a4769730
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https://lup.lub.lu.se/record/5e115992-c042-4cad-a118-6c77a4769730URI
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https://doi.org/10.1038/s44161-023-00295-xDOI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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The immune system is integral to cardiovascular health and disease. Targeting inflammation ameliorates adverse cardiovascular outcomes. Atherosclerosis, a major underlying cause of cardiovascular disease, is conceptualized as lipid-driven inflammation in which macrophages play a nonredundant role. However, evidence emerging so far from single-cell atlases suggests a dichotomy between lipid-associated and inflammatory macrophage states. Here, we present an inclusive reference atlas of human intraplaque immune cell communities. Combining single-cell RNA sequencing (scRNA-seq) of human surgical carotid endarterectomies in a discovery cohort with bulk RNA-seq and immunohistochemistry in a validation cohort (the Carotid Plaque Imaging Project), we reveal the existence of PLIN2hi/TREM1hi macrophages as a Toll-like receptor (TLR)-dependent inflammatory lipid-associated macrophage state linked to cerebrovascular events. Our study shifts the current paradigm of lipid-driven inflammation by providing biological evidence for a pathogenic macrophage transition to an inflammatory lipid-associated phenotype and for its targeting as a new treatment strategy for cardiovascular disease.
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Koneva, Lada A.University of Oxford
(author)
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Edsfeldt, AndreasLund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-aet
(author)
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Zurke, Yasemin XiomaraUniversity of Oxford
(author)
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Sun, JiangmingLund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups(Swepub:lu)med-js5
(author)
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Nitulescu, MihaelaLund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups(Swepub:lu)medf-mni
(author)
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Attar, MoustafaUniversity of Oxford
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Lutgens, EstherMayo Clinic Minnesota
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Schmidt, SteffenRoche Innovation Center Copenhagen
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Lindholm, Marie W.Roche Innovation Center Copenhagen(Swepub:lu)medf-mli
(author)
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Choudhury, Robin P.University of Oxford
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Cassimjee, IsmailUniversity of Oxford
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Lee, RegentUniversity of Oxford
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Handa, AshokUniversity of Oxford
(author)
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Goncalves, IsabelLund University,Lunds universitet,Kardiovaskulär forskning - translationella studier,Forskargrupper vid Lunds universitet,Cardiovascular Research - Translational Studies,Lund University Research Groups,Skåne University Hospital(Swepub:lu)medf-igo
(author)
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Sansom, Stephen N.University of Oxford
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Monaco, ClaudiaUniversity of Oxford
(author)
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University of OxfordKardiovaskulär forskning - translationella studier
(creator_code:org_t)
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In:Nature Cardiovascular Research2:7, s. 656-6722731-0590
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Dib, Lea
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Koneva, Lada A.
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Edsfeldt, Andrea ...
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Zurke, Yasemin X ...
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Sun, Jiangming
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Nitulescu, Mihae ...
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Attar, Moustafa
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Lutgens, Esther
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Schmidt, Steffen
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Lindholm, Marie ...
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Cassimjee, Ismai ...
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Lee, Regent
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Handa, Ashok
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Goncalves, Isabe ...
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Monaco, Claudia
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