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Effect of nicotine ...
Effect of nicotine 6 mg gum on urges to smoke, a randomized clinical trial
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- Hansson, Anna (författare)
- McNeil AB
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- Rasmussen, Thomas (författare)
- McNeil AB
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- Perfekt, Roland (författare)
- McNeil AB
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- Hall, Elin (författare)
- McNeil AB
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- Kraiczi, Holger (författare)
- Lund University,Lunds universitet,Statistiska institutionen,Ekonomihögskolan,Department of Statistics,Lund University School of Economics and Management, LUSEM
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(creator_code:org_t)
- 2019-11-21
- 2019
- Engelska.
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Ingår i: BMC Pharmacology and Toxicology. - : Springer Science and Business Media LLC. - 2050-6511. ; 20:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://bmcpharmacol...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: Ability to manage urges to smoke is fundamental to maximizing the chances of success in smoking cessation. Previous studies have linked a higher dose of nicotine in nicotine replacement therapy to a higher success rate for smoking cessation. Thus, this study was performed to compare relief of urges to smoke, up until 5 h following treatment with a new 6 mg nicotine gum versus currently marketed 4 mg nicotine gum. Methods: This was a randomized crossover clinical study. Following 12 h of abstinence from smoking, either one 6 mg or one 4 mg nicotine gum was given to 240 healthy adult smokers. Thereafter, urges to smoke were scored on a 100 mm Visual Analogue Scale repeatedly over 5 h. Results: The reductions in urges to smoke over the first 1 and 3 h after administration were statistically significantly greater with 6 mg than 4 mg gum, (p < 0.005). A 50% reduction in perceived urges to smoke was reached in 9.4 min with 6 mg gum compared to 16.2 min with 4 mg gum (median values). The median duration of a 50% or more reduction in VAS urges to smoke score was 111 min with the 6 mg gum, versus 74 min for the 4 mg gum. Conclusion: This study provides evidence that the 6 mg nicotine gum provided a greater reduction, faster and longer relief of urges to smoke than the 4 mg nicotine gum. Trial registration: EudraCT Number: 2010-023268-42. Study was first entered in EudraCT 2011-02-23.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Beroendelära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Substance Abuse (hsv//eng)
Nyckelord
- Clinical trial
- Craving relief
- Nicotine replacement therapy
- Smoking cessation
- Urges to smoke
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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