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Tumour microvessel ...
Tumour microvessel density as predictor of chemotherapy response in breast cancer patients
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Tynninen, O (author)
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Sjostrom, J (author)
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von Boguslawski, K (author)
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Bengtsson, NO (author)
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Heikkila, R (author)
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- Malmström, Per (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Ostenstad, B (author)
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Wist, E (author)
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Valvere, V (author)
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Saksela, E (author)
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Paavonen, T (author)
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- Blomqvist, Carl (author)
- Uppsala universitet,Institutionen för onkologi, radiologi och klinisk immunologi
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(creator_code:org_t)
- 2002-06-11
- 2002
- English.
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In: British Journal of Cancer. - : Springer Science and Business Media LLC. - 1532-1827 .- 0007-0920. ; 86:12, s. 1905-1908
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Abstract
Subject headings
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- The aim of this study was to evaluate the predictive value of intratumoural microvessel density in breast cancer. We studied immunohistochemically primary tumours of 104 patients with metastasised breast cancer who took part in a randomised multicentre trial comparing docetaxel to sequential methotrexate and 5-fluorouracil. Vessels were highlighted with factor VIII staining and counted microscopically. Microvessel density was compared with clinical response to chemotherapy and patient survival. The microvessel density of the primary tumour was not significantly associated with patient's response to chemotherapy, time to progression or overall survival in the whole patient population or in the docetaxel or methotrexate and 5-fluorouracil groups. However, disease-free survival was longer in patients with low microvessel density (P=0.01). These findings suggest that microvessel density of the primary tumour cannot be used as a predictive marker for chemotherapy response in advanced breast cancer.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- metastatic breast cancer
- microvessel density
- chemotherapy
- predictive
- factor
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Tynninen, O
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Sjostrom, J
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von Boguslawski, ...
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Bengtsson, NO
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Heikkila, R
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Malmström, Per
-
show more...
-
Ostenstad, B
-
Wist, E
-
Valvere, V
-
Saksela, E
-
Paavonen, T
-
Blomqvist, Carl
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
- Articles in the publication
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British Journal ...
- By the university
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Lund University
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Uppsala University