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Assessment of lifes...
Assessment of lifestyle factors helps to identify liver fibrosis due to non-alcoholic fatty liver disease in obesity
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- Lahelma, Mari (författare)
- University of Helsinki,Helsinki University Central Hospital,Minerva Foundation Institute for Medical Research
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- Luukkonen, Panu K. (författare)
- University of Helsinki,Helsinki University Central Hospital,Minerva Foundation Institute for Medical Research,Yale University
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- Qadri, Sami (författare)
- University of Helsinki,Helsinki University Central Hospital,Minerva Foundation Institute for Medical Research
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- Ahlholm, Noora (författare)
- Helsinki University Central Hospital,Minerva Foundation Institute for Medical Research,University of Helsinki
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- Lallukka-Brück, Susanna (författare)
- University of Helsinki,Helsinki University Central Hospital,Minerva Foundation Institute for Medical Research
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- Porthan, Kimmo (författare)
- University of Helsinki,Minerva Foundation Institute for Medical Research,Helsinki University Central Hospital
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- Juuti, Anne (författare)
- Helsinki University Central Hospital
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- Sammalkorpi, Henna (författare)
- Helsinki University Central Hospital
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- Penttilä, Anne K. (författare)
- Helsinki University Central Hospital
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- Arola, Johanna (författare)
- Helsinki University Central Hospital,University of Helsinki
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- Orho-Melander, Marju (författare)
- Lund University,Lunds universitet,Diabetes - kardiovaskulär sjukdom,Forskargrupper vid Lunds universitet,Diabetes - Cardiovascular Disease,Lund University Research Groups
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- Yki-Järvinen, Hannele (författare)
- University of Helsinki,Helsinki University Central Hospital,Minerva Foundation Institute for Medical Research
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(creator_code:org_t)
- 2021-01-08
- 2021
- Engelska 13 s.
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Ingår i: Nutrients. - : MDPI AG. - 2072-6643. ; 13:1
- Relaterad länk:
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http://dx.doi.org/10... (free)
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https://www.mdpi.com...
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https://lup.lub.lu.s...
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https://doi.org/10.3...
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Abstract
Ämnesord
Stäng
- Only some individuals with obesity develop liver fibrosis due to non-alcoholic fatty liver disease (NAFLD-fibrosis). We determined whether detailed assessment of lifestyle factors in addition to physical, biochemical and genetic factors helps in identification of these patients. A total of 100 patients with obesity (mean BMI 40.0 ± 0.6 kg/m2 ) referred for bariatric surgery at the Helsinki University Hospital underwent a liver biopsy to evaluate liver histology. Physical activity was determined by accelerometer recordings and by the Modifiable Activity Questionnaire, diet by the FINRISK Food Frequency Questionnaire, and other lifestyle factors, such as sleep patterns and smoking, by face-to-face interviews. Physical and biochemical parameters and genetic risk score (GRS based on variants in PNPLA3, TM6SF2, MBOAT7 and HSD17B13) were measured. Of all participants 49% had NAFLD-fibrosis. Independent predictors of NAFLD-fibrosis were low moderate-to-vigorous physical activity, high red meat intake, low carbohydrate intake, smoking, HbA1c, triglycerides and GRS. A model including these factors (areas under the receiver operating characteristics curve (AUROC) 0.90 (95% CI 0.84–0.96)) identified NAFLD-fibrosis significantly more accurately than a model including all but lifestyle factors (AUROC 0.82 (95% CI 0.73–0.91)) or models including lifestyle, physical and biochemical, or genetic factors alone. Assessment of lifestyle parameters in addition to physical, biochemical and genetic factors helps to identify obese patients with NAFLD-fibrosis.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Gastroenterologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Nyckelord
- Diet
- Glucose
- Insulin
- Physical activity
- Stress
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Lahelma, Mari
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Luukkonen, Panu ...
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Qadri, Sami
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Ahlholm, Noora
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Lallukka-Brück, ...
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Porthan, Kimmo
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visa fler...
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Juuti, Anne
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Sammalkorpi, Hen ...
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Penttilä, Anne K ...
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Arola, Johanna
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Orho-Melander, M ...
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Yki-Järvinen, Ha ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Gastroenterologi
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Hälsovetenskap
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och Folkhälsovetensk ...
- Artiklar i publikationen
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Nutrients
- Av lärosätet
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Lunds universitet