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Healing of tympanic...
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Magnuson, KarinUmeå University
(författare)
Healing of tympanic membrane after myringotomy during Streptococcus pneumoniae otitis media : An otomicroscopic and histologic study in the rat
- Artikel/kapitelEngelska1996
Förlag, utgivningsår, omfång ...
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2016-06-29
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SAGE Publications,1996
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8 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:6fc10051-45cf-49c2-b71c-ef6bb8bf4b73
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https://lup.lub.lu.se/record/6fc10051-45cf-49c2-b71c-ef6bb8bf4b73URI
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https://doi.org/10.1177/000348949610500513DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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The purpose of our study was to elucidate the course of healing of the tympanic membrane (TM) when myringotomy was performed during acute otitis media. The early and long-lasting structural changes of the TM were studied in an animal model. Rats were inoculated with Streptococcus pneumoniae (PnC) type 3 in the bulla. When the infection was manifest, myringotomy was performed. On days 4 and 12, and 3 and 6 months after myringotomy, the TM status was checked by otomicroscopy and TMs were prepared for light and electron microscopy. Comparison was made with PnC-infected TMs that were not perforated, as well as myringotomized noninfected TMs. The infection resolved more slowly in myringotomized ears compared to PnC-infected ears that were left untouched. After 6 months, the pars tensa of the myringotomized infected ears was thickened and showed a disorganized collagen structure, compared with myringotomized noninfected ears, in which TMs were normalized. The PnC- infected TMs without myringotomy were completely normalized after 2 months. We conclude that a combination of bacterial infection and myringotomy causes long-lasting changes in TM structure. This impaired structure of the connective tissue could be of importance in chronic middle ear disease as a presumptive site for retraction and perforation of the TM.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Hermansson, AnnLund University,Lunds universitet,Öron-, näs- och halssjukdomar, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Otorhinolaryngology (Lund),Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine(Swepub:lu)onh-ahe
(författare)
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Hellström, StenUmeå University
(författare)
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Umeå UniversityÖron-, näs- och halssjukdomar, Lund
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Annals of Otology, Rhinology and Laryngology: SAGE Publications105:5, s. 397-4040003-48941943-572X
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