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Sökning: onr:"swepub:oai:lup.lub.lu.se:708ad83b-e785-4939-a1e8-0a490cc2e94d" > Quantitative outcom...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005283naa a2200541 4500
001oai:lup.lub.lu.se:708ad83b-e785-4939-a1e8-0a490cc2e94d
003SwePub
008170616s2017 | |||||||||||000 ||eng|
0247 a https://lup.lub.lu.se/record/708ad83b-e785-4939-a1e8-0a490cc2e94d2 URI
0247 a https://doi.org/10.1016/j.mvr.2017.05.0032 DOI
040 a (SwePub)lu
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dinsdale, Grahamu University of Manchester4 aut
2451 0a Quantitative outcome measures for systemic sclerosis-related Microangiopathy – Reliability of image acquisition in Nailfold Capillaroscopy
264 1b Elsevier BV,c 2017
520 a Background Nailfold capillaroscopic parameters hold increasing promise as outcome measures for clinical trials in systemic sclerosis (SSc). Their inclusion as outcomes would often naturally require capillaroscopy images to be captured at several time points during any one study. Our objective was to assess repeatability of image acquisition (which has been little studied), as well as of measurement. Method 41 patients (26 with SSc, 15 with primary Raynaud's phenomenon) and 10 healthy controls returned for repeat high-magnification (300 ×) videocapillaroscopy mosaic imaging of 10 digits one week after initial imaging (as part of a larger study of reliability). Images were assessed in a random order by an expert blinded observer and 4 outcome measures extracted: (1) overall image grade and then (where possible) distal vessel locations were marked, allowing (2) vessel density (across the whole nailfold) to be calculated (3) apex width measurement and (4) giant vessel count. Intra-rater, intra-visit and intra-rater inter-visit (baseline vs. 1 week) reliability were examined in 475 and 392 images respectively. A linear, mixed-effects model was used to estimate variance components, from which intra-class correlation coefficients (ICCs) were determined. Results Intra-visit and inter-visit reliability estimates (ICCs) were (respectively): overall image grade, 0.97 and 0.90; vessel density, 0.92 and 0.65; mean vessel width, 0.91 and 0.79; presence of giant capillary, 0.68 and 0.56. These estimates were conditional on each parameter being measurable. Conclusion Within-operator image analysis and acquisition are reproducible. Quantitative nailfold capillaroscopy, at least with a single observer, provides reliable outcome measures for clinical studies including randomised controlled trials.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reumatologi och inflammation0 (SwePub)302102 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Rheumatology and Autoimmunity0 (SwePub)302102 hsv//eng
653 a Nailfold videocapillaroscopy
653 a Raynaud's phenomenon
653 a Reliability
653 a Systemic sclerosis
7001 a Moore, Tonia Lu Great Ormond Street Hospital4 aut
7001 a O'Leary, Neilu University of Manchester4 aut
7001 a Berks, Michaelu University of Manchester4 aut
7001 a Roberts, Christopheru University of Manchester4 aut
7001 a Manning, Joanne Bu Great Ormond Street Hospital4 aut
7001 a Allen, Johnu Freeman Hospital4 aut0 (Swepub:lu)pcel-jal
7001 a Anderson, Marinau University of Liverpool4 aut
7001 a Cutolo, Mauriziou University of Genoa4 aut
7001 a Hesselstrand, Rogeru Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups4 aut0 (Swepub:lu)reum-rhe
7001 a Howell, Kevinu University College London4 aut
7001 a Pizzorni, Carmenu University of Genoa4 aut
7001 a Smith, Vanessau Ghent University4 aut
7001 a Sulli, Albertou University of Genoa4 aut
7001 a Wildt, Marieu Lund University,Lunds universitet,Reumatologi och molekylär skelettbiologi,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskargruppen för systemisk skleros, Lund,Forskargrupper vid Lunds universitet,Rheumatology,Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Systemic Sclerosis Research Group,Lund University Research Groups4 aut0 (Swepub:lu)reum-mwi
7001 a Taylor, Christopheru University of Manchester4 aut
7001 a Murray, Andreau University of Manchester4 aut
7001 a Herrick, Ariane Lu University of Manchester4 aut
7102 a University of Manchesterb Great Ormond Street Hospital4 org
7730 t Microvascular Researchd : Elsevier BVg 113, s. 56-59q 113<56-59x 0026-2862
8564 u http://dx.doi.org/10.1016/j.mvr.2017.05.003y FULLTEXT
8564 u https://www.research.manchester.ac.uk/portal/files/60638619/RSA_paper_2_MVR_04_05_2017_FINAL_revised.pdf
8564 8u https://lup.lub.lu.se/record/708ad83b-e785-4939-a1e8-0a490cc2e94d
8564 8u https://doi.org/10.1016/j.mvr.2017.05.003

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