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Sökning: onr:"swepub:oai:lup.lub.lu.se:756b3155-c9a3-4608-9909-87fce930e342" > Characterisation of...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04186naa a2200457 4500 | |
| 001 | oai:lup.lub.lu.se:756b3155-c9a3-4608-9909-87fce930e342 | |
| 003 | SwePub | |
| 008 | 230815s2023 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://lup.lub.lu.se/record/756b3155-c9a3-4608-9909-87fce930e3422 URI |
| 024 | 7 | a https://doi.org/10.3390/nu151126382 DOI |
| 040 | a (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a art2 swepub-publicationtype |
| 072 | 7 | a ref2 swepub-contenttype |
| 100 | 1 | a Bermingham, Kate M.u King's College London4 aut |
| 245 | 1 0 | a Characterisation of Fasting and Postprandial NMR Metabolites : Insights from the ZOE PREDICT 1 Study |
| 264 | 1 | c 2023 |
| 520 | a Background: Postprandial metabolomic profiles and their inter-individual variability are not well characterised. Here, we describe postprandial metabolite changes, their correlations with fasting values and their inter- and intra-individual variability, following a standardised meal in the ZOE PREDICT 1 cohort. Methods: In the ZOE PREDICT 1 study (n = 1002 (NCT03479866)), 250 metabolites, mainly lipids, were measured by a Nightingale NMR panel in fasting and postprandial (4 and 6 h after a 3.7 MJ mixed nutrient meal, with a second 2.2 MJ mixed nutrient meal at 4 h) serum samples. For each metabolite, inter- and intra-individual variability over time was evaluated using linear mixed modelling and intraclass correlation coefficients (ICC) were calculated. Results: Postprandially, 85% (of 250 metabolites) significantly changed from fasting at 6 h (47% increased, 53% decreased; Kruskal–Wallis), with 37 measures increasing by >25% and 14 increasing by >50%. The largest changes were observed in very large lipoprotein particles and ketone bodies. Seventy-one percent of circulating metabolites were strongly correlated (Spearman’s rho >0.80) between fasting and postprandial timepoints, and 5% were weakly correlated (rho <0.50). The median ICC of the 250 metabolites was 0.91 (range 0.08–0.99). The lowest ICCs (ICC <0.40, 4% of measures) were found for glucose, pyruvate, ketone bodies (β-hydroxybutyrate, acetoacetate, acetate) and lactate. Conclusions: In this large-scale postprandial metabolomic study, circulating metabolites were highly variable between individuals following sequential mixed meals. Findings suggest that a meal challenge may yield postprandial responses divergent from fasting measures, specifically for glycolysis, essential amino acid, ketone body and lipoprotein size metabolites. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng |
| 653 | a lipids | |
| 653 | a lipoproteins | |
| 653 | a nuclear magnetic resonance (NMR) | |
| 700 | 1 | a Mazidi, Mohsenu University of Oxford,King's College London4 aut |
| 700 | 1 | a Franks, Paul W.u Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups,Harvard University4 aut0 (Swepub:lu)med-plf |
| 700 | 1 | a Maher, Tyleru King's College London4 aut |
| 700 | 1 | a Valdes, Ana M.u University of Nottingham4 aut |
| 700 | 1 | a Linenberg, Inbaru King's College London4 aut |
| 700 | 1 | a Wolf, Jonathan4 aut |
| 700 | 1 | a Hadjigeorgiou, George4 aut |
| 700 | 1 | a Spector, Tim D.u King's College London4 aut |
| 700 | 1 | a Menni, Cristinau King's College London4 aut |
| 700 | 1 | a Ordovas, Jose M.u CIBER de Fisiopatología Obesidad y Nutricion (CIBEROBN),Madrid Institute For Advanced Studies (IMDEA) Food Institute,Jean Mayer USDA Human Nutrition Research Center on Aging4 aut |
| 700 | 1 | a Berry, Sarah E.u King's College London4 aut |
| 700 | 1 | a Hall, Wendy L.u King's College London4 aut |
| 710 | 2 | a King's College Londonb University of Oxford4 org |
| 773 | 0 | t Nutrientsg 15:11q 15:11x 2072-6643 |
| 856 | 4 | u http://dx.doi.org/10.3390/nu15112638x freey FULLTEXT |
| 856 | 4 8 | u https://lup.lub.lu.se/record/756b3155-c9a3-4608-9909-87fce930e342 |
| 856 | 4 8 | u https://doi.org/10.3390/nu15112638 |
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