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Natural clusters of...
Natural clusters of tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND) : new findings from the TOSCA TAND research project
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- de Vries, Petrus J (author)
- University of Cape Town
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- Belousova, Elena (author)
- Pirogov Russian National Research Medical University (RNRMU)
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- Benedik, Mirjana P (author)
- University Medical Centre Ljubljana
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- Carter, Tom (author)
- TSA Tuberous Sclerosis Association, UK
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- Cottin, Vincent (author)
- Laboratoire Lyon République
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- Curatolo, Paolo (author)
- Tor Vergata University Hospital
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- D'Amato, Lisa (author)
- Novartis Farma S.p.A
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- Beure d'Augères, Guillaume (author)
- Association Sclérose Tubéreuse de Bourneville
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- Ferreira, José C (author)
- Centro Hospitalar de Lisboa Ocidental (CHLO)
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- Feucht, Martha (author)
- Universitatsklinik fur Kinder-und Jugendheilkunde, Vienna
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- Fladrowski, Carla (author)
- Associazione Sclerosi Tuberosa ONLUS
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- Hertzberg, Christoph (author)
- Vivantes Hospital Neukölln
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- Jozwiak, Sergiusz (author)
- Medical University of Warsaw
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- Lawson, John A (author)
- Sydney Children's Hospital
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- Macaya, Alfons (author)
- Vall d'Hebron University Hospital
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- Marques, Ruben (author)
- Novartis Farma S.p.A
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- Nabbout, Rima (author)
- Paris Descartes University
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- O'Callaghan, Finbar (author)
- University College London Hospital
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- Qin, Jiong (author)
- Peking University People's Hospital
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- Sander, Valentin (author)
- Tallinn Children's Hospital
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- Sauter, Matthias (author)
- Klinikum Kempten-Oberallgäu
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- Shah, Seema (author)
- University of Hyderabad
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- Takahashi, Yukitoshi (author)
- National Epilepsy Center, Shizuoka Institute of Epilepsy and Neurological Disorders
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- Touraine, Renaud (author)
- Fox Chase Cancer Center
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- Youroukos, Sotiris (author)
- Aghia Sophia Children's Hospital
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- Zonnenberg, Bernard (author)
- Hanyang University Medical Center
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- Kingswood, J Chris (author)
- University of London
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- Jansen, Anna C (author)
- Universitair Ziekenhuis Brussel
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- Rask, Olof (creator_code:cre_t)
- Lund University,Lunds universitet,Barn- och ungdomspsykiatri,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Child and Adolescent Psychiatry,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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(creator_code:org_t)
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- 2020-09-01
- 2020
- English.
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In: Journal of Neurodevelopmental Disorders. - : Springer Science and Business Media LLC. - 1866-1955 .- 1866-1947. ; 12:1, s. 24-24
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Abstract
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- BACKGROUND: Tuberous sclerosis complex (TSC)-associated neuropsychiatric disorders (TAND) have unique, individual patterns that pose significant challenges for diagnosis, psycho-education, and intervention planning. A recent study suggested that it may be feasible to use TAND Checklist data and data-driven methods to generate natural TAND clusters. However, the study had a small sample size and data from only two countries. Here, we investigated the replicability of identifying natural TAND clusters from a larger and more diverse sample from the TOSCA study.METHODS: As part of the TOSCA international TSC registry study, this embedded research project collected TAND Checklist data from individuals with TSC. Correlation coefficients were calculated for TAND variables to generate a correlation matrix. Hierarchical cluster and factor analysis methods were used for data reduction and identification of natural TAND clusters.RESULTS: A total of 85 individuals with TSC (female:male, 40:45) from 7 countries were enrolled. Cluster analysis grouped the TAND variables into 6 clusters: a scholastic cluster (reading, writing, spelling, mathematics, visuo-spatial difficulties, disorientation), a hyperactive/impulsive cluster (hyperactivity, impulsivity, self-injurious behavior), a mood/anxiety cluster (anxiety, depressed mood, sleep difficulties, shyness), a neuropsychological cluster (attention/concentration difficulties, memory, attention, dual/multi-tasking, executive skills deficits), a dysregulated behavior cluster (mood swings, aggressive outbursts, temper tantrums), and an autism spectrum disorder (ASD)-like cluster (delayed language, poor eye contact, repetitive behaviors, unusual use of language, inflexibility, difficulties associated with eating). The natural clusters mapped reasonably well onto the six-factor solution generated. Comparison between cluster and factor solutions from this study and the earlier feasibility study showed significant similarity, particularly in cluster solutions.CONCLUSIONS: Results from this TOSCA research project in an independent international data set showed that the combination of cluster analysis and factor analysis may be able to identify clinically meaningful natural TAND clusters. Findings were remarkably similar to those identified in the earlier feasibility study, supporting the potential robustness of these natural TAND clusters. Further steps should include examination of larger samples, investigation of internal consistency, and evaluation of the robustness of the proposed natural clusters.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
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- ref (subject category)
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- By the author/editor
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de Vries, Petrus ...
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Belousova, Elena
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Benedik, Mirjana ...
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Carter, Tom
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Cottin, Vincent
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Curatolo, Paolo
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D'Amato, Lisa
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Beure d'Augères, ...
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Ferreira, José C
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Feucht, Martha
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Fladrowski, Carl ...
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Hertzberg, Chris ...
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Jozwiak, Sergius ...
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Lawson, John A
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Macaya, Alfons
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Marques, Ruben
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Nabbout, Rima
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O'Callaghan, Fin ...
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Qin, Jiong
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Sander, Valentin
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Sauter, Matthias
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Shah, Seema
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Takahashi, Yukit ...
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Touraine, Renaud
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Youroukos, Sotir ...
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Zonnenberg, Bern ...
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Kingswood, J Chr ...
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Jansen, Anna C
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Rask, Olof
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Neurology
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MEDICAL AND HEAL ...
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and Psychiatry
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Lund University