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Sökning: onr:"swepub:oai:lup.lub.lu.se:7bd447a6-41c3-4699-9907-5350e355429e" > Chlamydia trachomat...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00003827naa a2200397 4500
001oai:lup.lub.lu.se:7bd447a6-41c3-4699-9907-5350e355429e
003SwePub
008160401s2010 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:120103690
0247 a https://lup.lub.lu.se/record/15897792 URI
0247 a https://doi.org/10.1186/1471-230X-10-192 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1201036902 URI
040 a (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a art2 swepub-publicationtype
072 7a ref2 swepub-contenttype
1001 a Dlugosz, Aldonau Karolinska Institutet4 aut
2451 0a Chlamydia trachomatis antigens in enteroendocrine cells and macrophages of the small bowel in patients with severe irritable bowel syndrome
264 1c 2010
520 a Background: Inflammation and immune activation have repeatedly been suggested as pathogentic factors in irritable bowel syndrome (IBS). The driving force for immune activation in IBS remains unknown. The aim of our study was to find out if the obligate intracellular pathogen Chlamydia could be involved in the pathogenesis of IBS. Methods: We studied 65 patients (61 females) with IBS and 42 (29 females) healthy controls in which IBS had been excluded. Full thickness biopsies from the jejunum and mucosa biopsies from the duodenum and the jejunum were stained with a monoclonal antibody to Chlamydia lipopolysaccharide (LPS) and species-specific monoclonal antibodies to C. trachomatis and C. pneumoniae. We used polyclonal antibodies to chromogranin A, CD68, CD11c, and CD117 to identify enteroendocrine cells, macrophages, dendritic, and mast cells, respectively. Results: Chlamydia LPS was present in 89% of patients with IBS, but in only 14% of healthy controls (p < 0.001) and 79% of LPS-positive biopsies were also positive for C. trachomatis major outer membrane protein (MOMP). Staining for C. pneumoniae was negative in both patients and controls. Chlamydia LPS was detected in enteroendocrine cells of the mucosa in 90% of positive biopsies and in subepithelial macrophages in 69% of biopsies. Biopsies taken at different time points in 19 patients revealed persistence of Chlamydia LPS up to 11 years. The odds ratio for the association of Chlamydia LPS with presence of IBS (43.1; 95% CI: 13.2-140.7) is much higher than any previously described pathogenetic marker in IBS. Conclusions: We found C. trachomatis antigens in enteroendocrine cells and macrophages in the small bowel mucosa of patients with IBS. Further studies are required to clarify if the presence of such antigens has a role in the pathogenesis of IBS.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
7001 a Tornblom, Hansu Karolinska Institutet4 aut
7001 a Mohammadian, Ghazalehu Karolinska Institutet4 aut
7001 a Morgan, Garethu Karolinska Institutet4 aut
7001 a Veress, Belau Lund University,Lunds universitet,Patologi, Malmö,Forskargrupper vid Lunds universitet,Pathology, Malmö,Lund University Research Groups4 aut0 (Swepub:lu)pat-bve
7001 a Edvinsson, Benjamin4 aut
7001 a Sandstrom, Gunnaru Karolinska Institutet4 aut
7001 a Lindberg, Gregeru Karolinska Institutet4 aut
7102 a Karolinska Institutetb Patologi, Malmö4 org
7730 t BMC Gastroenterologyg 10q 10x 1471-230X
8564 u http://dx.doi.org/10.1186/1471-230X-10-19x freey FULLTEXT
8564 8u https://lup.lub.lu.se/record/1589779
8564 8u https://doi.org/10.1186/1471-230X-10-19
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:120103690

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