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Activity-dependent ...
Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in subiculum
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- Toft Sörensen, Andreas (författare)
- Lund University,Lunds universitet,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Experimental Epilepsy Group,Lund University Research Groups
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- Kanter Schlifke, Irene (författare)
- Lund University,Lunds universitet,Wallenberg Neurocentrum, Lund,Medicinska fakulteten,Wallenberg Neuroscience Centre, Lund,Faculty of Medicine
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Lin, En-Ju D. (författare)
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During, Matthew J. (författare)
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- Kokaia, Merab (författare)
- Lund University,Lunds universitet,Epilepsicentrum,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell Epilepsi,Forskargrupper vid Lunds universitet,Epilepsy Center,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Epilepsy Group,Lund University Research Groups
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(creator_code:org_t)
- Elsevier BV, 2008
- 2008
- Engelska.
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Ingår i: Molecular and Cellular Neuroscience. - : Elsevier BV. - 1044-7431. ; 39:2, s. 37-229
- Relaterad länk:
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http://www.ncbi.nlm.... (free)
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http://www.sciencedi...
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http://dx.doi.org/10... (free)
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic regions can effectively suppress seizures in animals, and is being considered as a promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to understand the detailed mechanisms governing the release and action of transgene NPY in neuronal circuitries. Using whole-cell recordings from subicular neurons, we show that in animals transduced by recombinant adeno-associated viral (rAAV) vector carrying the NPY gene, transgene NPY is released during high-frequency activation of CA1-subicular synapses. Released transgene NPY attenuates excitatory synaptic transmission not only in activated, but also in neighboring, non-activated synapses. Such broad action of transgene NPY may prevent recruitment of excitatory synapses in epileptic activity and could play a key role in limiting the spread and generalization of seizures.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- Long-term potentiation (LTP)
- Activity-dependent release
- Synaptic transmission
- Synaptic plasticity
- Neuropeptide Y
- Gene therapy
- Whole-cell patch-clamp
- Subiculum
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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