Sökning: onr:"swepub:oai:lup.lub.lu.se:7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed" > Targets of compleme...
Fältnamn | Indikatorer | Metadata |
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000 | 04381naa a2200493 4500 | |
001 | oai:lup.lub.lu.se:7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed | |
003 | SwePub | |
008 | 190215s2019 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed2 URI |
024 | 7 | a https://doi.org/10.1038/s41467-019-08528-z2 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Reiling, Lindau Burnet Institute4 aut |
245 | 1 0 | a Targets of complement-fixing antibodies in protective immunity against malaria in children |
264 | c 2019-02-05 | |
264 | 1 | b Springer Science and Business Media LLC,c 2019 |
520 | a Antibodies against P. falciparum merozoites fix complement to inhibit blood-stage replication in naturally-acquired and vaccine-induced immunity; however, specific targets of these functional antibodies and their importance in protective immunity are unknown. Among malaria-exposed individuals, we show that complement-fixing antibodies to merozoites are more strongly correlated with protective immunity than antibodies that inhibit growth quantified using the current reference assay for merozoite vaccine evaluation. We identify merozoite targets of complement-fixing antibodies and identify antigen-specific complement-fixing antibodies that are strongly associated with protection from malaria in a longitudinal study of children. Using statistical modelling, combining three different antigens targeted by complement-fixing antibodies could increase the potential protective effect to over 95%, and we identify antigens that were common in the most protective combinations. Our findings support antibody-complement interactions against merozoite antigens as important anti-malaria immune mechanisms, and identify specific merozoite antigens for further evaluation as vaccine candidates. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Immunologi inom det medicinska området0 (SwePub)301102 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Immunology in the medical area0 (SwePub)301102 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Infektionsmedicin0 (SwePub)302092 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Infectious Medicine0 (SwePub)302092 hsv//eng |
700 | 1 | a Boyle, Michelle J.u Burnet Institute4 aut |
700 | 1 | a White, Michael T.u Pasteur Institute4 aut |
700 | 1 | a Wilson, Danny W.u Burnet Institute,University of Adelaide4 aut |
700 | 1 | a Feng, Gaoqianu University of Melbourne,Burnet Institute4 aut |
700 | 1 | a Weaver, Rupertu Burnet Institute4 aut |
700 | 1 | a Opi, D. Herbertu Monash University,Burnet Institute4 aut |
700 | 1 | a Persson, Kristina E.M.u Lund University,Lunds universitet,Avdelningen för klinisk kemi och farmakologi,Institutionen för laboratoriemedicin,Medicinska fakulteten,Malaria och Babesia,Forskargrupper vid Lunds universitet,Division of Clinical Chemistry and Pharmacology,Department of Laboratory Medicine,Faculty of Medicine,Malaria and Babesia,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)klke-kpe |
700 | 1 | a Richards, Jack S.u Burnet Institute,University of Melbourne4 aut |
700 | 1 | a Siba, Peter M.u Papua New Guinea Institute of Medical Research4 aut |
700 | 1 | a Fowkes, Freya J.I.u Monash University,Burnet Institute,University of Melbourne,Royal Melbourne Hospital4 aut |
700 | 1 | a Takashima, Eizou Ehime University4 aut |
700 | 1 | a Tsuboi, Takafumiu Ehime University4 aut |
700 | 1 | a Mueller, Ivou Papua New Guinea Institute of Medical Research,Pasteur Institute,Walter and Eliza Hall Institute of Medical Research4 aut |
700 | 1 | a Beeson, James G.u Royal Melbourne Hospital,Monash University,Burnet Institute,University of Melbourne4 aut |
710 | 2 | a Burnet Instituteb Pasteur Institute4 org |
773 | 0 | t Nature Communicationsd : Springer Science and Business Media LLCg 10:1q 10:1x 2041-1723 |
856 | 4 | u http://dx.doi.org/10.1038/s41467-019-08528-zx freey FULLTEXT |
856 | 4 | u https://doi.org/10.1038/s41467-019-08528-z |
856 | 4 8 | u https://lup.lub.lu.se/record/7db6b5cf-c753-41e0-a2bb-7c1b9d0f3eed |
856 | 4 8 | u https://doi.org/10.1038/s41467-019-08528-z |
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