Sodium-glucose co-transporter inhibitors and atrial fibrillation : A systematic review and meta-analysis of randomized controlled trials

↓ Direkt till sidans innehåll
↓ Direkt till sidans sekundära innehåll (sidomenyn)

Search: onr:"swepub:oai:lup.lub.lu.se:7e5ad58d-dc98-4497-98bf-501fb0a766c5" > Sodium-glucose co-t...

1 of 1
Previous record
Next record
To hitlist

Sodium-glucose co-transporter inhibitors and atrial fibrillation : A systematic review and meta-analysis of randomized controlled trials

Pandey, Arjun K. (author): McMaster University

Okaj, Iva (author): McMaster University

Kaur, Hargun (author): McMaster University

Belley-Cote, Emilie P. (author): McMaster University,Population Health Research Institute, Ontario

Wang, Jia-xiang (author): Population Health Research Institute, Ontario

Oraii, Alireza (author): University of Tehran

Benz, Alexander P. (author): Population Health Research Institute, Ontario

Johnson, Linda S.B. (author): Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups

Young, Jack (author): McMaster University

Wong, Jorge A. (author): Population Health Research Institute, Ontario,McMaster University

Verma, Subodh (author): Saint Michael's Hospital

Conen, David (author): McMaster University,Population Health Research Institute, Ontario

Gerstein, Hertzel (author): McMaster University,Population Health Research Institute, Ontario

Healey, Jeff S. (author): McMaster University

McIntyre, William F. (author): McMaster University,Population Health Research Institute, Ontario

show less...

(creator_code:org_t)

2021
2021
English.
In: Journal of the American Heart Association. - 2047-9980. ; 10:17

Related links:: http://dx.doi.org/10... (free); show more...; https://lup.lub.lu.s...; https://doi.org/10.1...; show less...

Journal article (peer-reviewed)

Abstract Subject headings

BACKGROUND: Sodium-glucose co-transporter (SGLT) inhibitors reduce cardiovascular outcomes including mortality in several populations; however, their effect on atrial fibrillation/flutter (AF) remains unclear. Our objective was to determine whether SGLT inhibitors reduce AF and whether a history of AF modifies the effect of SGLT inhibitors on the composite of heart failure hospitalization or cardiovascular death. METHODS AND RESULTS: We searched MEDLINE, Embase, and CENTRAL to March 2021. Pairs of reviewers identified randomized controlled trials that compared an SGLT inhibitor with placebo or no therapy. We pooled data using RevMan 5.4.1, assessed risk of bias using the Cochrane tool, and determined the overall quality of evidence using Grades of Recommendation, Assessment, Development and Evaluation. Thirty-one eligible trials reported on AF events (75 279 participants, mean age 62 years, 35.0% women). Moderate quality evidence supported a lower risk of serious AF events with SGLT inhibitors (1.1% versus 1.5%; risk ratio 0.75 [95% CI, 0.66–0.86]; I2=0%). A similar reduction in total AF events was also noted with SGLT inhibitors. Three trials reported on heart failure hospitalization/cardiovascular death stratified by a baseline history of AF (18 832 participants, mean age 66 years, 38.1% women); in patients with a history of AF, SGLT inhibitors resulted in a lower risk in the composite of heart failure hospitalization or cardiovascular death (hazard ratio, 0.70 [95% CI, 0.57–0.85]; I2=0%)—similar to the effect estimate for patients without AF, P value for interaction: 1.00. CONCLUSIONS: SGLT inhibitors may reduce AF events and likely reduce heart failure hospitalization/cardiovascular death to a similar extent in patients with and without AF.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

Atrial fibrillation
Atrial flutter
Gliflozins
SGLT inhibitors

Publication and Content Type

art (subject category)
ref (subject category)

Find in a library

Journal of the American Heart Association (Search for host publication in LIBRIS)

To the university's database

1 of 1
Previous record
Next record
To hitlist

Find more in SwePub

By the author/editor: Pandey, Arjun K.; Okaj, Iva; Kaur, Hargun; Belley-Cote, Emi ...; Wang, Jia-xiang; Oraii, Alireza; show more...; Benz, Alexander ...; Johnson, Linda S ...; Young, Jack; Wong, Jorge A.; Verma, Subodh; Conen, David; Gerstein, Hertze ...; Healey, Jeff S.; McIntyre, Willia ...; show less...

About the subject

MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Clinical Medicin ...; and Cardiac and Card ...

Articles in the publication: Journal of the A ...

By the university: Lund University

Search outside SwePub

Extend your search to:: Google; Google Book Search; Google Scholar

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

LIBRIS.kb.se