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Non-functioning pit...
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Borghammar, CamillaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
(författare)
Non-functioning pituitary microadenoma in children and adolescents : Is follow-up with diagnostic imaging necessary?
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2022-10-17
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Springer Science and Business Media LLC,2023
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:7e685571-b99f-4319-8daa-a46cd6f9dbaa
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https://lup.lub.lu.se/record/7e685571-b99f-4319-8daa-a46cd6f9dbaaURI
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https://doi.org/10.1007/s12020-022-03212-7DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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PURPOSE: No consensus exists regarding follow-up recommendations for suspected pituitary microadenoma in children. To address this knowledge gap, we investigated the growth potential of pituitary solid and cystic lesions <10 mm in children and evaluated the accuracy of magnetic resonance imaging (MRI) measurements.METHODS: The children included were <18 years at first pituitary MRI and radiologically diagnosed with a non-functioning microadenoma or cyst <10 mm. Lesion size at first and latest MRI as well as all individual MRI examinations were re-evaluated.RESULTS: In total, 74 children, median age 12 years (range 3-17), had a non-functioning microadenoma, probable microadenoma, or cyst. Of these, 55 underwent repeated MRI (median 3, range 2-7) with a median follow-up of 37 months (range 4-189). None of the pituitary lesions without hormonal disturbances increased significantly during follow-up. Two radiologists agreed that no lesion could be identified in 38/269 (14%) MRI examinations, and in 51/231 (22%) they disagreed about lesion location. In 34/460 (7%) MRI measurements size differed >2 mm, which had been considered significant progression.CONCLUSION: Non-functioning pituitary microadenoma in children has small size variations, often below the spatial resolution of the scanners. We suggest lesions <4 mm only for clinical follow-up, lesions 4-6 mm for MRI after 2 years and ≥7 mm MRI after 1 and 3 years, with clinical follow-up in between. If no progression, further MRI should only be performed after new clinical symptoms or hormonal disturbances.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Tamaddon, AshkanLund University,Lunds universitet,Diagnostisk radiologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Diagnostic Radiology, (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital(Swepub:lu)as2852ta
(författare)
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Erfurth, Eva-MarieLund University,Lunds universitet,Endokrin,Forskargrupper vid Lunds universitet,Endocrine,Lund University Research Groups,Skåne University Hospital(Swepub:lu)med-ee0
(författare)
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Sundgren, Pia CLund University,Lunds universitet,Lund University Bioimaging Center,Medicinska fakulteten,Neuroradiologi,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Faculty of Medicine,Neuroradiology,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)med-psu
(författare)
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Siesjö, PeterLund University,Lunds universitet,Glioma immunterapigrupp,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Glioma immunotherapy group,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)nkir-psi
(författare)
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Elfving, MariaLund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Childhood Cancer Research Unit,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Skåne University Hospital(Swepub:lu)pedi-mel
(författare)
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Nilsson, MargaretaLund University,Skåne University Hospital
(författare)
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Pediatrik, LundSektion V
(creator_code:org_t)
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Ingår i:Endocrine: Springer Science and Business Media LLC79, s. 152-1601355-008X1559-0100
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