Sökning: onr:"swepub:oai:lup.lub.lu.se:8625e4b3-5b86-42c9-a8ed-1d2f56000208" > Loci associated wit...
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000 | 04914naa a2200457 4500 | |
001 | oai:lup.lub.lu.se:8625e4b3-5b86-42c9-a8ed-1d2f56000208 | |
003 | SwePub | |
008 | 200330s2020 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/8625e4b3-5b86-42c9-a8ed-1d2f560002082 URI |
024 | 7 | a https://doi.org/10.1016/j.mrgentox.2020.5031672 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Corredor, Zurayu Autonomous University of Barcelona4 aut |
245 | 1 0 | a Loci associated with genomic damage levels in chronic kidney disease patients and controls |
264 | 1 | b Elsevier BV,c 2020 |
520 | a Chronic kidney disease (CKD) is a multifactorial disorder with an important genetic component, and several studies have demonstrated potential associations with allelic variants. In addition, CKD patients are also characterized by high levels of genomic damage. Nevertheless, no studies have established relationships between DNA damage, or genomic instability present in CKD patients, and gene polymorphisms. To fill in this gap, the potential role of polymorphisms in genes involved in base excision repair (OGG1, rs1052133; MUTYH, rs3219489; XRCC1, rs25487), nucleotide excision repair (ERCC2/XPD, rs1799793, rs171140, rs13181; ERCC4, rs3136166); phase II metabolism (GSTP1, rs749174; GSTO1, rs2164624; GSTO2, rs156697), and antioxidant enzymes (SOD1, rs17880135, rs1041740, rs202446; SOD2, rs4880; CAT, rs1001179; GPX1, rs17080528; GPX3, rs870406: GPX4, rs713041) were inquired. In addition, some genes involved in CKD (AGT, rs5050; GLO1, rs386572987; SHROOM3, rs17319721) were also evaluated. The genomic damage, the genomic instability, and oxidative damage were evaluated by using the micronucleus and the comet assay in 589 donors (415 CKD patients and 174 controls). Our results showed significant associations between genomic damage and genes directly involved in DNA repair pathways (XRCC1, and ERCC2), and with genes encoding for antioxidant enzymes (SOD1 and GPX1). GSTO2, as a gene involved in phase II metabolism, and MUTYH showed also an association with genomic instability. Interestingly, the three genes associated with CKD (AGT, GLO1, and SHROOM3) showed associations with both the high levels of oxidatively damaged DNA and genomic instability. These results support our view that genomic instability can be considered a biomarker of the CKD status. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a CKD patients | |
653 | a Genomic damage | |
653 | a Single nucleotide polymorphisms | |
700 | 1 | a da Silva Filho, Miguel Ináciou German Cancer Research Centre4 aut0 (Swepub:lu)med-md_ |
700 | 1 | a Rodríguez-Ribera, Larau Autonomous University of Barcelona4 aut |
700 | 1 | a Catalano, Calogerinau German Cancer Research Centre4 aut |
700 | 1 | a Hemminki, Kariu Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,German Cancer Research Centre,Center for Primary Health Care Research4 aut0 (Swepub:lu)med-khk |
700 | 1 | a Coll, Elisabethu Fundació Puigvert4 aut |
700 | 1 | a Silva, Ireneu Fundació Puigvert4 aut |
700 | 1 | a Diaz, Juan Manuelu Fundació Puigvert4 aut |
700 | 1 | a Ballarin, José Aureliou Fundació Puigvert4 aut |
700 | 1 | a Henández, Albau Carlos III Health Institute,Autonomous University of Barcelona4 aut |
700 | 1 | a Försti, Astau Lund University,Lunds universitet,Allmänmedicin, kardiovaskulär epidemiologi och levnadsvanor,Forskargrupper vid Lunds universitet,Allmänmedicin och klinisk epidemiologi,Family Medicine, Cardiovascular Epidemiology and Lifestyle,Lund University Research Groups,Family Medicine and Clinical Epidemiology,Center for Primary Health Care Research,German Cancer Research Centre4 aut0 (Swepub:lu)med-asf |
700 | 1 | a Marcos, Ricardu Carlos III Health Institute,Autonomous University of Barcelona4 aut |
700 | 1 | a Pastor, Susanau Autonomous University of Barcelona,Carlos III Health Institute4 aut |
710 | 2 | a Autonomous University of Barcelonab German Cancer Research Centre4 org |
773 | 0 | t Mutation Research - Genetic Toxicology and Environmental Mutagenesisd : Elsevier BVg 852q 852x 1383-5718 |
856 | 4 | u http://dx.doi.org/10.1016/j.mrgentox.2020.503167y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/8625e4b3-5b86-42c9-a8ed-1d2f56000208 |
856 | 4 8 | u https://doi.org/10.1016/j.mrgentox.2020.503167 |
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