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Heritability of var...
Heritability of variation in glycaemic response to metformin: a genome-wide complex trait analysis.
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Zhou, Kaixin (author)
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Donnelly, Louise (author)
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Yang, Jian (author)
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Li, Miaoxin (author)
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Deshmukh, Harshal (author)
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Van Zuydam, Natalie (author)
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- Ahlqvist, Emma (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Spencer, Chris C (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Morris, Andrew D (author)
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Colhoun, Helen M (author)
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Sham, Pak C (author)
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McCarthy, Mark I (author)
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Palmer, Colin N A (author)
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Pearson, Ewan R (author)
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(creator_code:org_t)
- 2014
- 2014
- English.
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In: The Lancet Diabetes & Endocrinology. - 2213-8595. ; 2:6, s. 481-487
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http://dx.doi.org/10...
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Abstract
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- Metformin is a first-line oral agent used in the treatment of type 2 diabetes, but glycaemic response to this drug is highly variable. Understanding the genetic contribution to metformin response might increase the possibility of personalising metformin treatment. We aimed to establish the heritability of glycaemic response to metformin using the genome-wide complex trait analysis (GCTA) method.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
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- art (subject category)
- ref (subject category)
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- By the author/editor
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Zhou, Kaixin
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Donnelly, Louise
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Yang, Jian
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Li, Miaoxin
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Deshmukh, Harsha ...
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Van Zuydam, Nata ...
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show more...
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Ahlqvist, Emma
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Spencer, Chris C
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Groop, Leif
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Morris, Andrew D
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Colhoun, Helen M
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Sham, Pak C
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McCarthy, Mark I
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Palmer, Colin N ...
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Pearson, Ewan R
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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The Lancet Diabe ...
- By the university
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Lund University