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  • Kapur, RickSaint Michael's Hospital,Canadian Blood Services (author)

T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10

  • Article/chapterEnglish2017

Publisher, publication year, extent ...

  • American Society of Hematology,2017
  • 13 s.

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:89f9ca8a-4fc5-49cf-b026-af0a680807cb
  • https://lup.lub.lu.se/record/89f9ca8a-4fc5-49cf-b026-af0a680807cbURI
  • https://doi.org/10.1182/blood-2016-12-758185DOI

Supplementary language notes

  • Language:English
  • Summary in:English

Part of subdatabase

Classification

  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4+CD25+FoxP3+ T regulatory cells (Tregs) and CD11c+ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Kim, MichaelSaint Michael's Hospital (author)
  • Aslam, RukhsanaSaint Michael's Hospital (author)
  • McVey, Mark JSaint Michael's Hospital (author)
  • Tabuchi, ArataUniversity of Toronto (author)
  • Luo, AliceUniversity of Toronto (author)
  • Liu, JonathanSaint Michael's Hospital (author)
  • Li, YuanShandong University (author)
  • Shanmugabhavananthan, ShanjeevanSaint Michael's Hospital (author)
  • Speck, Edwin RSaint Michael's Hospital (author)
  • Zufferey, AnneSaint Michael's Hospital (author)
  • Yousef, George (author)
  • Zhang, Haibo (author)
  • Rondina, Matthew T (author)
  • Weyrich, Andrew S (author)
  • Porcelijn, Leendert (author)
  • Kuebler, Wolfgang M (author)
  • Slutsky, Arthur S (author)
  • Semple, John WLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Saint Michael's Hospital,Canadian Blood Services,University of Toronto(Swepub:lu)jo0201se (author)
  • Saint Michael's HospitalCanadian Blood Services (creator_code:org_t)

Related titles

  • In:Blood: American Society of Hematology129:18, s. 2557-25691528-00200006-4971

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