Search: onr:"swepub:oai:lup.lub.lu.se:89f9ca8a-4fc5-49cf-b026-af0a680807cb" >
T regulatory cells ...
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Kapur, RickSaint Michael's Hospital,Canadian Blood Services
(author)
T regulatory cells and dendritic cells protect against transfusion-related acute lung injury via IL-10
- Article/chapterEnglish2017
Publisher, publication year, extent ...
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American Society of Hematology,2017
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13 s.
Numbers
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LIBRIS-ID:oai:lup.lub.lu.se:89f9ca8a-4fc5-49cf-b026-af0a680807cb
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https://lup.lub.lu.se/record/89f9ca8a-4fc5-49cf-b026-af0a680807cbURI
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https://doi.org/10.1182/blood-2016-12-758185DOI
Supplementary language notes
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Language:English
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Summary in:English
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Classification
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
Notes
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Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related fatalities and is characterized by acute respiratory distress following blood transfusion. Donor antibodies are frequently involved; however, the pathogenesis and protective mechanisms in the recipient are poorly understood, and specific therapies are lacking. Using newly developed murine TRALI models based on injection of anti-major histocompatibility complex class I antibodies, we found CD4+CD25+FoxP3+ T regulatory cells (Tregs) and CD11c+ dendritic cells (DCs) to be critical effectors that protect against TRALI. Treg or DC depletion in vivo resulted in aggravated antibody-mediated acute lung injury within 90 minutes with 60% mortality upon DC depletion. In addition, resistance to antibody-mediated TRALI was associated with increased interleukin-10 (IL-10) levels, and IL-10 levels were found to be decreased in mice suffering from TRALI. Importantly, IL-10 injection completely prevented and rescued the development of TRALI in mice and may prove to be a promising new therapeutic approach for alleviating lung injury in this serious complication of transfusion.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
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Kim, MichaelSaint Michael's Hospital
(author)
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Aslam, RukhsanaSaint Michael's Hospital
(author)
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McVey, Mark JSaint Michael's Hospital
(author)
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Tabuchi, ArataUniversity of Toronto
(author)
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Luo, AliceUniversity of Toronto
(author)
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Liu, JonathanSaint Michael's Hospital
(author)
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Li, YuanShandong University
(author)
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Shanmugabhavananthan, ShanjeevanSaint Michael's Hospital
(author)
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Speck, Edwin RSaint Michael's Hospital
(author)
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Zufferey, AnneSaint Michael's Hospital
(author)
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Yousef, George
(author)
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Zhang, Haibo
(author)
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Rondina, Matthew T
(author)
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Weyrich, Andrew S
(author)
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Porcelijn, Leendert
(author)
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Kuebler, Wolfgang M
(author)
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Slutsky, Arthur S
(author)
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Semple, John WLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Saint Michael's Hospital,Canadian Blood Services,University of Toronto(Swepub:lu)jo0201se
(author)
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Saint Michael's HospitalCanadian Blood Services
(creator_code:org_t)
Related titles
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In:Blood: American Society of Hematology129:18, s. 2557-25691528-00200006-4971
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Kapur, Rick
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Kim, Michael
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Aslam, Rukhsana
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McVey, Mark J
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Tabuchi, Arata
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Luo, Alice
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Liu, Jonathan
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Li, Yuan
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Shanmugabhavanan ...
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Speck, Edwin R
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Zufferey, Anne
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Yousef, George
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Zhang, Haibo
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Rondina, Matthew ...
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Weyrich, Andrew ...
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Porcelijn, Leend ...
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Kuebler, Wolfgan ...
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Slutsky, Arthur ...
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Semple, John W
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