Sökning: onr:"swepub:oai:lup.lub.lu.se:8d0338b1-a706-443a-9628-cccecfb2f3de" > Mother's Genome or ...
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000 | 04102naa a2200613 4500 | |
001 | oai:lup.lub.lu.se:8d0338b1-a706-443a-9628-cccecfb2f3de | |
003 | SwePub | |
008 | 160401s2009 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/14625652 URI |
024 | 7 | a https://doi.org/10.1159/0002246412 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Plunkett, Jevon4 aut |
245 | 1 0 | a Mother's Genome or Maternally-Inherited Genes Acting in the Fetus Influence Gestational Age in Familial Preterm Birth |
264 | c 2009-06-11 | |
264 | 1 | b S. Karger AG,c 2009 |
520 | a Objective: While multiple lines of evidence suggest the importance of genetic contributors to risk of preterm birth, the nature of the genetic component has not been identified. We perform segregation analyses to identify the best fitting genetic model for gestational age, a quantitative proxy for preterm birth. Methods: Because either mother or infant can be considered the proband from a preterm delivery and there is evidence to suggest that genetic factors in either one or both may influence the trait, we performed segregation analysis for gestational age either attributed to the infant (infant's gestational age), or the mother (by averaging the gestational ages at which her children were delivered), using 96 multiplex preterm families. Results: These data lend further support to a genetic component contributing to birth timing since sporadic (i.e. no familial resemblance) and nontransmission (i.e. environmental factors alone contribute to gestational age) models are strongly rejected. Analyses of gestational age attributed to the infant support a model in which mother's genome and/or maternally-inherited genes acting in the fetus are largely responsible for birth timing, with a smaller contribution from the paternally-inherited alleles in the fetal genome. Conclusion: Our findings suggest that genetic influences on birth timing are important and likely complex. Copyright (C) 2009 S. Karger AG, Basel | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
653 | a Imprinting | |
653 | a Maternal effects | |
653 | a Segregation analysis | |
653 | a Preterm birth | |
653 | a Gestational age | |
653 | a Genetic model | |
700 | 1 | a Feitosa, Mary F.4 aut |
700 | 1 | a Trusgnich, Michelle4 aut |
700 | 1 | a Wangler, Michael F.4 aut |
700 | 1 | a Palomar, Lisanne4 aut |
700 | 1 | a Kistka, Zachary A. -F.4 aut |
700 | 1 | a DeFranco, Emily A.4 aut |
700 | 1 | a Shen, Tammy T.4 aut |
700 | 1 | a Stormo, Adrienne E. D.4 aut |
700 | 1 | a Puttonen, Hilkka4 aut |
700 | 1 | a Hallman, Mikko4 aut |
700 | 1 | a Haataja, Ritva4 aut |
700 | 1 | a Luukkonen, Aino4 aut |
700 | 1 | a Fellman, Vinetau Lund University,Lunds universitet,Pediatrik, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Paediatrics (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)pedi-vfe |
700 | 1 | a Peltonen, Leena4 aut |
700 | 1 | a Palotie, Aarnou Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)med-aop |
700 | 1 | a Daw, E. Warwick4 aut |
700 | 1 | a An, Ping4 aut |
700 | 1 | a Teramo, Kari4 aut |
700 | 1 | a Borecki, Ingrid4 aut |
700 | 1 | a Muglia, Louis J.4 aut |
710 | 2 | a Pediatrik, Lundb Sektion V4 org |
773 | 0 | t Human Heredityd : S. Karger AGg 68:3, s. 209-219q 68:3<209-219x 1423-0062x 0001-5652 |
856 | 4 | u http://dx.doi.org/10.1159/000224641y FULLTEXT |
856 | 4 | u https://www.karger.com/Article/Pdf/224641 |
856 | 4 8 | u https://lup.lub.lu.se/record/1462565 |
856 | 4 8 | u https://doi.org/10.1159/000224641 |
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