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The association bet...
The association between weight at birth and breast cancer risk revisited using Mendelian randomisation
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- Kar, Siddhartha P. (author)
- University of Cambridge
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- Andrulis, Irene L. (author)
- University of Toronto,Mount Sinai Hospital of University of Toronto
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- Brenner, Hermann (author)
- National Centre of Tumor Diseases,German Cancer Research Centre
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- Burgess, Stephen (author)
- University of Cambridge
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- Chang-Claude, Jenny (author)
- German Cancer Research Centre,University Medical Center Hamburg-Eppendorf
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- Considine, Daniel (author)
- University of Cambridge
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- Dörk, Thilo (author)
- Hannover Medical School
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- Evans, Dafydd Gareth R. (author)
- University of Manchester
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- Gago-Domínguez, Manuela (author)
- University of California, San Diego,Complejo Hospitalario Universitario de Santiago,University of Santiago de Compostela
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- Giles, Graham G. (author)
- University of Melbourne,Cancer Council Victoria
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- Hartman, Mikael (author)
- National University of Singapore
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- Huo, Dezheng (author)
- University of Chicago
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- Kaaks, Rudolf (author)
- German Cancer Research Centre
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- Li, Jingmei (author)
- A*Star, Genome Institute of Singapore (GIS)
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- Lophatananon, Artitaya (author)
- University of Manchester
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- Margolin, Sara (author)
- Karolinska Institutet,Karolinska Institute,Stockholm South General Hospital
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- Milne, Roger L. (author)
- University of Melbourne,Cancer Council Victoria
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- Muir, Kenneth R. (author)
- University of Manchester
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- Olsson, Håkan (author)
- Lund University,Lunds universitet,Lunds Melanomstudiegrupp,Forskargrupper vid Lunds universitet,Lund Melanoma Study Group,Lund University Research Groups
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- Punie, Kevin (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Radice, Paolo (author)
- Istituto Nazionale dei Tumori
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- Simard, Jacques (author)
- Centre hospitalier universitaire de Québec,Laval University
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- Tamimi, Rulla M. (author)
- Harvard University,Brigham and Women's Hospital / Harvard Medical School
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- Van Nieuwenhuysen, Els (author)
- Catholic University of Leuven,University Hospitals Leuven
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- Wendt, Camilla (author)
- Karolinska Institute,Stockholm South General Hospital
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- Zheng, Wei (author)
- Vanderbilt University
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- Pharoah, Paul D.P. (author)
- University of Cambridge
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(creator_code:org_t)
- 2019-02-08
- 2019
- English.
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In: European Journal of Epidemiology. - : Springer Science and Business Media LLC. - 0393-2990 .- 1573-7284. ; 34:6, s. 591-600
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Abstract
Subject headings
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- Observational studies suggest that higher birth weight (BW) is associated with increased risk of breast cancer in adult life. We conducted a two-sample Mendelian randomisation (MR) study to assess whether this association is causal. Sixty independent single nucleotide polymorphisms (SNPs) known to be associated at P < 5 × 10 −8 with BW were used to construct (1) a 41-SNP instrumental variable (IV) for univariable MR after removing SNPs with pleiotropic associations with other breast cancer risk factors and (2) a 49-SNP IV for multivariable MR after filtering SNPs for data availability. BW predicted by the 41-SNP IV was not associated with overall breast cancer risk in inverse-variance weighted (IVW) univariable MR analysis of genetic association data from 122,977 breast cancer cases and 105,974 controls (odds ratio = 0.86 per 500 g higher BW; 95% confidence interval 0.73–1.01). Sensitivity analyses using four alternative methods and three alternative IVs, including an IV with 59 of the 60 BW-associated SNPs, yielded similar results. Multivariable MR adjusting for the effects of the 49-SNP IV on birth length, adult height, adult body mass index, age at menarche, and age at menopause using IVW and MR-Egger methods provided estimates consistent with univariable analyses. Results were also similar when all analyses were repeated after restricting to estrogen receptor-positive or -negative breast cancer cases. Point estimates of the odds ratios from most analyses performed indicated an inverse relationship between genetically-predicted BW and breast cancer, but we are unable to rule out an association between the non-genetically-determined component of BW and breast cancer. Thus, genetically-predicted higher BW was not associated with an increased risk of breast cancer in adult life in our MR study.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
Keyword
- Birth weight
- Breast cancer
- Mendelian randomisation
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kar, Siddhartha ...
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Andrulis, Irene ...
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Brenner, Hermann
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Burgess, Stephen
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Chang-Claude, Je ...
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Considine, Danie ...
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show more...
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Dörk, Thilo
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Evans, Dafydd Ga ...
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Gago-Domínguez, ...
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Giles, Graham G.
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Hartman, Mikael
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Huo, Dezheng
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Kaaks, Rudolf
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Li, Jingmei
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Lophatananon, Ar ...
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Margolin, Sara
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Milne, Roger L.
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Muir, Kenneth R.
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Olsson, Håkan
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Punie, Kevin
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Radice, Paolo
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Simard, Jacques
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Tamimi, Rulla M.
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Van Nieuwenhuyse ...
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Wendt, Camilla
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Zheng, Wei
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Pharoah, Paul D. ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Cancer and Oncol ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Health Sciences
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and Public Health Gl ...
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European Journal ...
- By the university
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Lund University
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Karolinska Institutet