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Tumour-associated m...
Tumour-associated macrophages drive stromal cell-dependent collagen crosslinking and stiffening to promote breast cancer aggression
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- Maller, Ori (författare)
- University of California, San Francisco
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- Drain, Allison P. (författare)
- University of California, San Francisco
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- Barrett, Alexander S. (författare)
- University of Colorado
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visa fler...
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- Borgquist, Signe (författare)
- Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Aarhus University,Aarhus University Hospital
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- Ruffell, Brian (författare)
- Oregon Health & Science University
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- Zakharevich, Igor (författare)
- University of Colorado
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- Pham, Thanh T. (författare)
- University of Colorado
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- Gruosso, Tina (författare)
- McGill University
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- Kuasne, Hellen (författare)
- McGill University
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- Lakins, Johnathon N. (författare)
- University of California, San Francisco
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- Acerbi, Irene (författare)
- University of California, San Francisco
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- Barnes, J. Matthew (författare)
- University of California, San Francisco
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- Nemkov, Travis (författare)
- University of Colorado
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- Chauhan, Aastha (författare)
- University of Minnesota
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- Gruenberg, Jessica (författare)
- University of Minnesota
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- Nasir, Aqsa (författare)
- University of Minnesota
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- Bjarnadottir, Olof (författare)
- Lund University,Lunds universitet,Bröstcancer - prevention & intervention,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breast cancer prevention & intervention,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments
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- Werb, Zena (författare)
- University of California, San Francisco,UCSF Helen Diller Family Comprehensive Cancer Center
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- Kabos, Peter (författare)
- University of Colorado
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- Chen, Yunn Yi (författare)
- University of California, San Francisco
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- Hwang, E. Shelley (författare)
- Duke University Medical Center
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- Park, Morag (författare)
- McGill University
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- Coussens, Lisa M. (författare)
- Oregon Health & Science University
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- Nelson, Andrew C. (författare)
- University of Minnesota
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- Hansen, Kirk C. (författare)
- McGill University,University of Colorado
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- Weaver, Valerie M. (författare)
- UCSF Helen Diller Family Comprehensive Cancer Center,University of California, San Francisco
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(creator_code:org_t)
- 2020-11-30
- 2020
- Engelska.
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Ingår i: Nature Materials. - : Springer Science and Business Media LLC. - 1476-1122 .- 1476-4660.
- Relaterad länk:
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http://dx.doi.org/10...
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https://www.ncbi.nlm...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Stromal stiffening accompanies malignancy, compromises treatment and promotes tumour aggression. Clarifying the molecular nature and the factors that regulate stromal stiffening in tumours should identify biomarkers to stratify patients for therapy and interventions to improve outcome. We profiled lysyl hydroxylase-mediated and lysyl oxidase-mediated collagen crosslinks and quantified the greatest abundance of total and complex collagen crosslinks in aggressive human breast cancer subtypes with the stiffest stroma. These tissues harbour the highest number of tumour-associated macrophages, whose therapeutic ablation in experimental models reduced metastasis, and decreased collagen crosslinks and stromal stiffening. Epithelial-targeted expression of the crosslinking enzyme, lysyl oxidase, had no impact on collagen crosslinking in PyMT mammary tumours, whereas stromal cell targeting did. Stromal cells in microdissected human tumours expressed the highest level of collagen crosslinking enzymes. Immunohistochemical analysis of biopsies from a cohort of patients with breast cancer revealed that stromal expression of lysyl hydroxylase 2, an enzyme that induces hydroxylysine aldehyde-derived collagen crosslinks and stromal stiffening, correlated significantly with disease specific mortality. The findings link tissue inflammation, stromal cell-mediated collagen crosslinking and stiffening to tumour aggression and identify lysyl hydroxylase 2 as a stromal biomarker.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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Till lärosätets databas
- Av författaren/redakt...
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Maller, Ori
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Drain, Allison P ...
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Barrett, Alexand ...
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Borgquist, Signe
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Ruffell, Brian
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Zakharevich, Igo ...
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visa fler...
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Pham, Thanh T.
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Gruosso, Tina
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Kuasne, Hellen
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Lakins, Johnatho ...
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Acerbi, Irene
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Barnes, J. Matth ...
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Nemkov, Travis
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Chauhan, Aastha
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Gruenberg, Jessi ...
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Nasir, Aqsa
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Bjarnadottir, Ol ...
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Werb, Zena
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Kabos, Peter
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Chen, Yunn Yi
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Hwang, E. Shelle ...
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Park, Morag
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Coussens, Lisa M ...
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Nelson, Andrew C ...
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Hansen, Kirk C.
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Weaver, Valerie ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
- Artiklar i publikationen
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Nature Materials
- Av lärosätet
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Lunds universitet