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Aortic effects of t...
Aortic effects of thyroid hormone in male mice
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- Gachkar, Sogol (författare)
- University of Lübeck
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- Nock, Sebastian (författare)
- University of Lübeck
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- Geissler, Cathleen (författare)
- University of Lübeck
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visa fler...
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- Oelkrug, Rebecca (författare)
- University of Lübeck
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- Johann, Kornelia (författare)
- University of Lübeck
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- Resch, Julia (författare)
- University of Lübeck
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- Rahman, Awahan (författare)
- Karolinska Institute
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- Arner, Anders (författare)
- Lund University,Lunds universitet,Kärlfysiologi,Forskargrupper vid Lunds universitet,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Vascular Physiology,Lund University Research Groups,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital
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- Kirchner, Henriette (författare)
- University of Lübeck
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- Mittag, Jens (författare)
- University of Lübeck
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(creator_code:org_t)
- 2019
- 2019
- Engelska 9 s.
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Ingår i: Journal of Molecular Endocrinology. - 1479-6813. ; 62:3, s. 91-99
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- It is well established that thyroid hormones are required for cardiovascular functions; however, the molecular mechanisms remain incompletely understood, especially the individual contributions of genomic and non-genomic signalling pathways. In this study, we dissected how thyroid hormones modulate aortic contractility. To test the immediate effects of thyroid hormones on vasocontractility, we used a wire myograph to record the contractile response of dissected mouse aortas to the adrenergic agonist phenylephrine in the presence of different doses of T3 (3,3',5-triiodothyronine). Interestingly, we observed reduced vasoconstriction under low and high T3 concentrations, indicating an inversed U-shaped curve with maximal constrictive capacity at euthyroid conditions. We then tested for possible genomic actions of thyroid hormones on vasocontractility by treating mice for 4 days with 1 mg/L thyroxine in drinking water. The study revealed that in contrast to the non-genomic actions the aortas of these animals were hyperresponsive to the contractile stimulus, an effect not observed in endogenously hyperthyroid TRβ knockout mice. To identify targets of genomic thyroid hormone action, we analysed aortic gene expression by microarray, revealing several altered genes including the well-known thyroid hormone target gene hairless. Taken together, the findings demonstrate that thyroid hormones regulate aortic tone through genomic and non-genomic actions, although genomic actions seem to prevail in vivo. Moreover, we identified several novel thyroid hormone target genes that could provide a better understanding of the molecular changes occurring in the hyperthyroid aorta.
Ämnesord
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Nyckelord
- aorta
- gene expression
- hyperthyroidism
- hypothyroidism
- thyroid hormone receptor β
- vasoconstriction
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Gachkar, Sogol
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Nock, Sebastian
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Geissler, Cathle ...
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Oelkrug, Rebecca
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Johann, Kornelia
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Resch, Julia
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visa fler...
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Rahman, Awahan
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Arner, Anders
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Kirchner, Henrie ...
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Mittag, Jens
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visa färre...
- Om ämnet
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- NATURVETENSKAP
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NATURVETENSKAP
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och Biologi
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och Genetik
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Medicinska och f ...
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och Medicinsk geneti ...
- Artiklar i publikationen
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Journal of Molec ...
- Av lärosätet
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Lunds universitet
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Karolinska Institutet