Sökning: onr:"swepub:oai:lup.lub.lu.se:9c7e0f0f-7442-411e-a0c2-32bad59098b3" >
SARS-CoV-2 Infectio...
-
Lugar, MarijaDresden University of Technology
(författare)
SARS-CoV-2 Infection and Development of Islet Autoimmunity in Early Childhood
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:9c7e0f0f-7442-411e-a0c2-32bad59098b3
-
https://lup.lub.lu.se/record/9c7e0f0f-7442-411e-a0c2-32bad59098b3URI
-
https://doi.org/10.1001/jama.2023.16348DOI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:art swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
IMPORTANCE: The incidence of diabetes in childhood has increased during the COVID-19 pandemic. Elucidating whether SARS-CoV-2 infection is associated with islet autoimmunity, which precedes type 1 diabetes onset, is relevant to disease etiology and future childhood diabetes trends.OBJECTIVE: To determine whether there is a temporal relationship between SARS-CoV-2 infection and the development of islet autoimmunity in early childhood.DESIGN, SETTING, AND PARTICIPANTS: Between February 2018 and March 2021, the Primary Oral Insulin Trial, a European multicenter study, enrolled 1050 infants (517 girls) aged 4 to 7 months with a more than 10% genetically defined risk of type 1 diabetes. Children were followed up through September 2022.EXPOSURE: SARS-CoV-2 infection identified by SARS-CoV-2 antibody development in follow-up visits conducted at 2- to 6-month intervals until age 2 years from April 2018 through June 2022.MAIN OUTCOMES AND MEASURES: The development of multiple (≥2) islet autoantibodies in follow-up in consecutive samples or single islet antibodies and type 1 diabetes. Antibody incidence rates and risk of developing islet autoantibodies were analyzed.RESULTS: Consent was obtained for 885 (441 girls) children who were included in follow-up antibody measurements from age 6 months. SARS-CoV-2 antibodies developed in 170 children at a median age of 18 months (range, 6-25 months). Islet autoantibodies developed in 60 children. Six of these children tested positive for islet autoantibodies at the same time as they tested positive for SARS-CoV-2 antibodies and 6 at the visit after having tested positive for SARS-CoV-2 antibodies. The sex-, age-, and country-adjusted hazard ratio for developing islet autoantibodies when the children tested positive for SARS-CoV-2 antibodies was 3.5 (95% CI, 1.6-7.7; P = .002). The incidence rate of islet autoantibodies was 3.5 (95% CI, 2.2-5.1) per 100 person-years in children without SARS-CoV-2 antibodies and 7.8 (95% CI, 5.3-19.0) per 100 person-years in children with SARS-CoV-2 antibodies (P = .02). Islet autoantibody risk in children with SARS-CoV-2 antibodies was associated with younger age (<18 months) of SARS-CoV-2 antibody development (HR, 5.3; 95% CI, 1.5-18.3; P = .009).CONCLUSION AND RELEVANCE: In young children with high genetic risk of type 1 diabetes, SARS-CoV-2 infection was temporally associated with the development of islet autoantibodies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Eugster, AnneDresden University of Technology
(författare)
-
Achenbach, PeterHelmholtz Zentrum München,Technical University of Munich
(författare)
-
von dem Berge, TheklaChildren's Hospital Auf der Bult
(författare)
-
Berner, ReinhardUniversity Clinic Carl Gustav Carus at the TU Dresden
(författare)
-
Besser, Rachel E JOxford University Hospital
(författare)
-
Casteels, KristinaCatholic University of Leuven,University Hospitals Leuven
(författare)
-
Elding Larsson, HelenaLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Skåne University Hospital(Swepub:lu)pedi-hla
(författare)
-
Gemulla, GitaUniversity Clinic Carl Gustav Carus at the TU Dresden,Dresden University of Technology
(författare)
-
Kordonouri, OlgaChildren's Hospital Auf der Bult
(författare)
-
Lindner, AnnettDresden University of Technology
(författare)
-
Lundgren, MarkusLund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Pediatrisk endokrinologi,Forskargrupper vid Lunds universitet,Department of Clinical Sciences, Malmö,Faculty of Medicine,Paediatric Endocrinology,Lund University Research Groups,Central Hospital Kristianstad(Swepub:lu)med-mn2
(författare)
-
Müller, DeniseDresden University of Technology
(författare)
-
Oltarzewski, MariuszNational Research Institute of Mother and Child
(författare)
-
Rochtus, AnneUniversity Hospitals Leuven,Catholic University of Leuven
(författare)
-
Scholz, MarlonTechnical University of Munich,Helmholtz Zentrum München
(författare)
-
Szypowska, AgnieszkaMedical University of Warsaw
(författare)
-
Todd, John AUniversity of Oxford
(författare)
-
Ziegler, Anette-GabrieleTechnical University of Munich,Helmholtz Zentrum München
(författare)
-
Bonifacio, EzioDresden University of Technology,Helmholtz Zentrum München,University Clinic Carl Gustav Carus at the TU Dresden
(författare)
-
Dresden University of TechnologyHelmholtz Zentrum München
(creator_code:org_t)
-
GPPAD Study Group
Sammanhörande titlar
-
Ingår i:JAMA330:120098-7484
Internetlänk
Hitta via bibliotek
-
JAMA
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas
- Av författaren/redakt...
-
Lugar, Marija
-
Eugster, Anne
-
Achenbach, Peter
-
von dem Berge, T ...
-
Berner, Reinhard
-
Besser, Rachel E ...
-
visa fler...
-
Casteels, Kristi ...
-
Elding Larsson, ...
-
Gemulla, Gita
-
Kordonouri, Olga
-
Lindner, Annett
-
Lundgren, Markus
-
Müller, Denise
-
Oltarzewski, Mar ...
-
Rochtus, Anne
-
Scholz, Marlon
-
Szypowska, Agnie ...
-
Todd, John A
-
Ziegler, Anette- ...
-
Bonifacio, Ezio
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Endokrinologi oc ...
- Artiklar i publikationen
-
JAMA
- Av lärosätet
-
Lunds universitet