Search: onr:"swepub:oai:lup.lub.lu.se:9ed84d39-a171-4364-836e-cb92b67c02b7" > The androgen recept...
Fältnamn | Indikatorer | Metadata |
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000 | 04466naa a2200541 4500 | |
001 | oai:lup.lub.lu.se:9ed84d39-a171-4364-836e-cb92b67c02b7 | |
003 | SwePub | |
008 | 161219s2016 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/9ed84d39-a171-4364-836e-cb92b67c02b72 URI |
024 | 7 | a https://doi.org/10.1530/EJE-16-04472 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Eendebak, Robert J A Hu University of Manchester4 aut |
245 | 1 0 | a The androgen receptor gene CAG repeat in relation to 4-year changes in androgen-sensitive endpoints in community-dwelling older European men |
264 | 1 | c 2016 |
300 | a 11 s. | |
520 | a Context: The androgen receptor (AR) gene exon 1 CAG repeat length has been proposed to be a determinant of between-individual variations in androgen action in target tissues, which might regulate phenotypic differences of human ageing. However, findings on its phenotypic effects are inconclusive. Objective: To assess whether the AR CAG repeat length is associated with longitudinal changes in endpoints that are influenced by testosterone (T) levels in middle-Aged and elderly European men. Design: Multinational European observational prospective cohort study. Participants: A total of 1887 men (mean ± s.d. age: 63 ± 11 years; median follow up: 4.3 years) from centres of eight European countries comprised the analysis sample after exclusion of those with diagnosed diseases of the hypothalamic-pituitary-testicular (HPT) axis. Main outcome measures: Longitudinal associations between the AR CAG repeat and changes in androgen-sensitive endpoints (ASEs) and medical conditions were assessed using regression analysis adjusting for age and centre. The AR CAG repeat length was treated as both a continuous and a categorical (6-20; 21-23; 24-39 repeats) predictor. Additional analysis investigated whether results were independent of baseline T or oestradiol (E2) levels. Results: The AR CAG repeat, when used as a continuous or a categorical predictor, was not associated with longitudinal changes in ASEs or medical conditions after adjustments. These results were independent of T and E2 levels. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
700 | 1 | a Huhtaniemi, Ilpo T.u Imperial College London4 aut |
700 | 1 | a Pye, Stephen R.u University of Manchester4 aut |
700 | 1 | a Ahern, Tomasu University of Manchester4 aut |
700 | 1 | a W O'Neill, Terenceu University of Manchester4 aut |
700 | 1 | a Bartfai, Györgyu University of Szeged4 aut |
700 | 1 | a Casanueva, Felipe F.u University of Santiago de Compostela4 aut |
700 | 1 | a Maggi, Mariou University of Florence4 aut |
700 | 1 | a Forti, Gianniu University of Florence4 aut |
700 | 1 | a Alston, Robert D.u University of Manchester4 aut |
700 | 1 | a Giwercman, Aleksanderu Lund University,Lunds universitet,Reproduktionsmedicin, Malmö,Forskargrupper vid Lunds universitet,Reproductive medicine, Malmö,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)kir-agi |
700 | 1 | a Han, Thang S.u University College London4 aut |
700 | 1 | a Kula, Krzysztofu Medical University of Lodz4 aut |
700 | 1 | a Lean, Michael E Ju University of Glasgow4 aut |
700 | 1 | a Punab, Margusu University of Tartu4 aut |
700 | 1 | a Pendleton, Neilu University of Manchester4 aut |
700 | 1 | a Keevil, Brian G.u University Hospital of South Manchester NHS Foundation Trust4 aut |
700 | 1 | a Vanderschueren, Dirku Catholic University of Leuven4 aut |
700 | 1 | a Rutter, Martin K.u Manchester University NHS Foundation Trust,University of Manchester4 aut |
700 | 1 | a Tampubolon, Gindou University of Manchester4 aut |
700 | 1 | a Goodacre, Roystonu University of Manchester4 aut |
700 | 1 | a Wu, Frederick C Wu University of Manchester4 aut |
710 | 2 | a University of Manchesterb Imperial College London4 org |
773 | 0 | t European Journal of Endocrinologyg 175:6, s. 583-593q 175:6<583-593x 0804-4643 |
856 | 4 | u http://dx.doi.org/10.1530/EJE-16-0447y FULLTEXT |
856 | 4 8 | u https://lup.lub.lu.se/record/9ed84d39-a171-4364-836e-cb92b67c02b7 |
856 | 4 8 | u https://doi.org/10.1530/EJE-16-0447 |
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