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A Relationship betw...
A Relationship between the Structures and Neurotoxic Effects of Aβ Oligomers Stabilized by Different Metal Ions
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- Chia, Sean (författare)
- University of Cambridge
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- Cataldi, Rodrigo Lessa (författare)
- University of Cambridge
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- Ruggeri, Francesco Simone (författare)
- University of Cambridge
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- Limbocker, Ryan (författare)
- University of Cambridge
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- Condado-Morales, Itzel (författare)
- University of Cambridge
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- Pisani, Katarina (författare)
- University of Cambridge
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- Possenti, Andrea (författare)
- University of Cambridge
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- Linse, Sara (författare)
- Lund University,Lunds universitet,NanoLund: Centre for Nanoscience,Annan verksamhet, LTH,Lunds Tekniska Högskola,Biokemi och Strukturbiologi,Centrum för Molekylär Proteinvetenskap,Kemiska institutionen,Institutioner vid LTH,LTH profilområde: Nanovetenskap och halvledarteknologi,LTH profilområden,Other operations, LTH,Faculty of Engineering, LTH,Biochemistry and Structural Biology,Center for Molecular Protein Science,Department of Chemistry,Departments at LTH,Faculty of Engineering, LTH,LTH Profile Area: Nanoscience and Semiconductor Technology,LTH Profile areas,Faculty of Engineering, LTH
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- Knowles, Tuomas P.J. (författare)
- University of Cambridge: Cavendish Laboratory,University of Cambridge
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- Habchi, Johnny (författare)
- University of Cambridge
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- Mannini, Benedetta (författare)
- University of Cambridge
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- Vendruscolo, Michele (författare)
- University of Cambridge
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(creator_code:org_t)
- 2024
- 2024
- Engelska 10 s.
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Ingår i: ACS Chemical Neuroscience. - 1948-7193. ; 15:6, s. 1125-1134
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Abstract
Ämnesord
Stäng
- Oligomeric assemblies of the amyloid β peptide (Aβ) have been investigated for over two decades as possible neurotoxic agents in Alzheimer’s disease. However, due to their heterogeneous and transient nature, it is not yet fully established which of the structural features of these oligomers may generate cellular damage. Here, we study distinct oligomer species formed by Aβ40 (the 40-residue form of Aβ) in the presence of four different metal ions (Al3+, Cu2+, Fe2+, and Zn2+) and show that they differ in their structure and toxicity in human neuroblastoma cells. We then describe a correlation between the size of the oligomers and their neurotoxic activity, which provides a type of structure-toxicity relationship for these Aβ40 oligomer species. These results provide insight into the possible role of metal ions in Alzheimer’s disease by the stabilization of Aβ oligomers.
Ämnesord
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Nyckelord
- Alzheimer’s disease
- amyloid-β peptide
- metal ions
- protein aggregation
- protein misfolding
- protein oligomers
Publikations- och innehållstyp
- art (ämneskategori)
- ref (ämneskategori)
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- Av författaren/redakt...
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Chia, Sean
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Cataldi, Rodrigo ...
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Ruggeri, Frances ...
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Limbocker, Ryan
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Condado-Morales, ...
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Pisani, Katarina
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visa fler...
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Possenti, Andrea
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Linse, Sara
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Knowles, Tuomas ...
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Habchi, Johnny
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Mannini, Benedet ...
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Vendruscolo, Mic ...
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visa färre...
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- NATURVETENSKAP
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ACS Chemical Neu ...
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Lunds universitet