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Autoantibodies agai...
Autoantibodies against red blood cell antigens are common in a Malaria endemic area
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- Saleh, Bandar Hasan (author)
- Lund University,Lunds universitet,Malaria och Babesia,Forskargrupper vid Lunds universitet,Malaria and Babesia,Lund University Research Groups,Skåne University Hospital,King Abdulaziz University
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- Lugaajju, Allan (author)
- Lund University,Lunds universitet,Malaria och Babesia,Forskargrupper vid Lunds universitet,Malaria and Babesia,Lund University Research Groups,Skåne University Hospital,Makerere University
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- Storry, Jill R (author)
- Lund University,Lunds universitet,Transfusionsmedicin,Forskargrupper vid Lunds universitet,Transfusion Medicine,Lund University Research Groups,Region Skåne
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- Persson, Kristina E M (author)
- Lund University,Lunds universitet,Malaria och Babesia,Forskargrupper vid Lunds universitet,Malaria and Babesia,Lund University Research Groups,Skåne University Hospital
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(creator_code:org_t)
- Elsevier BV, 2023
- 2023
- English.
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In: Microbes and Infection. - : Elsevier BV. - 1769-714X .- 1286-4579. ; 25:3
- Related links:
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http://dx.doi.org/10... (free)
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Abstract
Subject headings
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- Plasmodium falciparum malaria can cause severe anemia. Even after treatment, hematocrit can decrease. The role of autoantibodies against erythrocytes is not clearly elucidated and how common they are, or what they are directed against, is still largely unknown. We have investigated antibodies against erythrocytes in healthy adult men living in a highly malaria endemic area in Uganda. We found antibodies in more than half of the individuals, which is significantly more than in a non-endemic area (Sweden). Some of the Ugandan samples had a broad reactivity where it was not possible to determine the exact target of the autoantibodies, but we also found specific antibodies directed against erythrocyte surface antigens known to be of importance for merozoite invasion such as glycophorin A (anti-En a, anti-M) and glycophorin B (anti-U, anti-S). In addition, several autoantibodies had partial specificities against glycophorin C and the blood group systems Rh, Diego (located on Band 3), Duffy (located on ACKR1), and Cromer (located on CD55), all of which have been described to be important for malaria and therefore of interest for understanding how autoantibodies could potentially stop parasites from entering the erythrocyte. In conclusion, specific autoantibodies against erythrocytes are common in a malaria endemic area.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
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