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5-hydroxytryptamine...
5-hydroxytryptamine in the endocrine pancreas
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- Fex, Malin (författare)
- Lund University,Lunds universitet,-lup-obsolete,Forskargrupper vid Lunds universitet,Celiaki och diabetes,Diabetes - molekylär metabolism,LUDC (Lund University Diabetes Centre)-lup-obsolete,Lund University Research Groups,Celiac Disease and Diabetes Unit,Diabetes - Molecular Metabolism
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Pilowsky, Paul M (redaktör/utgivare)
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(creator_code:org_t)
- 2019
- 2019
- Engelska 10 s.
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Ingår i: Serotonin : The Mediator that Spans Evolution - The Mediator that Spans Evolution. - 9780128000502 ; , s. 81-90
- Relaterad länk:
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http://dx.doi.org/10...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main culprit in the development of type 2 diabetes, an ongoing global epidemic. In this context, 5-HT signaling may play a crucial role. In fact, serotonin (5-HT) is part of an intricate signaling network regulating release of insulin and glucagon, the main hormones that control lipid and glucose homeostasis. Several studies have focused on the role of 5-HT and signaling through various 5-HT receptors in pancreatic β-cells and effects on overall glucose metabolism. Here, we aim to discuss some of these issues.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- 5-HT receptors
- Islets of Langerhans
- α-cells insulin secretion
- β-cells
Publikations- och innehållstyp
- kap (ämneskategori)
- ref (ämneskategori)
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