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Acute Hemodynamic E...
Acute Hemodynamic Effects of Simultaneous and Sequential Multi-Point Pacing in Heart Failure Patients With an Expected Higher Rate of Sub-response to Cardiac Resynchronization Therapy : Results of Multicenter SYNSEQ Study
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- Sterliński, Maciej (författare)
- Cardinal Wyszynski National Institute of Cardiology
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- Zakrzewska-Koperska, Joanna (författare)
- Cardinal Wyszynski National Institute of Cardiology
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- Maciąg, Aleksander (författare)
- Cardinal Wyszynski National Institute of Cardiology
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- Sokal, Adam (författare)
- Silesian Center of Heart Disease
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- Osca-Asensi, Joaquin (författare)
- University and Polytechnic Hospital la Fe
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- Wang, Lingwei (författare)
- Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Arrhytmias and Cardiac Device treatment,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund University Research Groups
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- Spyropoulou, Vasiliki (författare)
- Medtronic Bakken Research Center, Maastricht
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- Maus, Baerbel (författare)
- Medtronic Bakken Research Center, Maastricht
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- Lemme, Francesca (författare)
- Medtronic Bakken Research Center, Maastricht
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- Okafor, Osita (författare)
- University of Birmingham
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- Stegemann, Berthold (författare)
- Aston University
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- Cornelussen, Richard (författare)
- Medtronic Bakken Research Center, Maastricht
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- Leyva, Francisco (författare)
- Aston University
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(creator_code:org_t)
- 2022-05-12
- 2022
- Engelska.
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Ingår i: Frontiers in Cardiovascular Medicine. - : Frontiers Media SA. - 2297-055X. ; 9, s. 1-10
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http://dx.doi.org/10... (free)
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Abstract
Ämnesord
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- The aim of the SYNSEQ (Left Ventricular Synchronous vs. Sequential MultiSpot Pacing for CRT) study was to evaluate the acute hemodynamic response (AHR) of simultaneous (3P-MPP syn) or sequential (3P-MPP seq) multi-3-point-left-ventricular (LV) pacing vs. single point pacing (SPP) in a group of patients at risk of a suboptimal response to cardiac resynchronization therapy (CRT). Twenty five patients with myocardial scar or QRS ≤ 150 or the absence of LBBB (age: 66 ± 12 years, QRS: 159 ± 12 ms, NYHA class II/III, LVEF ≤ 35%) underwent acute hemodynamic assessment by LV + dP/dtmax with a variety of LV pacing configurations at an optimized AV delay. The change in LV + dP/dt max (%ΔLV + dP/dt max) with 3P-MPP syn (15.6%, 95% CI: 8.8%-22.5%) was neither statistically significantly different to 3P-MPP seq (11.8%, 95% CI: 7.6-16.0%) nor to SPP basal (11.5%, 95% CI:7.1-15.9%) or SPP mid (12.2%, 95% CI:7.9-16.5%), but higher than SPP apical (10.6%, 95% CI:5.3-15.9%, p = 0.03). AHR (defined as a %ΔLV + dP/dt max ≥ 10%) varied between pacing configurations: 36% (9/25) for SPP apical, 44% (11/25) for SPP basal, 54% (13/24) for SPP mid, 56% (14/25) for 3P-MPP syn and 48% (11/23) for 3P-MPP seq.Fifteen patients (15/25, 60%) had an AHR in at least one pacing configuration. AHR was observed in 10/13 (77%) patients with a LBBB but only in 5/12 (42%) patients with a non-LBBB (p = 0.11). To conclude, simultaneous or sequential multipoint pacing compared to single point pacing did not improve the acute hemodynamic effect in a suboptimal CRT response population.Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT02914457.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
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Sterliński, Maci ...
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Zakrzewska-Koper ...
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Maciąg, Aleksand ...
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Sokal, Adam
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Osca-Asensi, Joa ...
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Wang, Lingwei
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Spyropoulou, Vas ...
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Maus, Baerbel
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Lemme, Francesca
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Okafor, Osita
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Stegemann, Berth ...
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Cornelussen, Ric ...
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Leyva, Francisco
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