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Integrative analysi...
Integrative analysis of prognostic biomarkers derived from multiomics panels helps discrimination of chronic kidney disease trajectories in people with type 2 diabetes
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- Kammer, Michael (author)
- Medical University of Vienna
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- Heinzel, Andreas (author)
- Medical University of Vienna
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- Willency, Jill A. (author)
- Eli Lilly and Company
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- Duffin, Kevin L. (author)
- Eli Lilly and Company
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- Mayer, Gert (author)
- Medical University of Innsbruck
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- Simons, Kai (author)
- Lipotype GmbH
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- Gerl, Mathias J. (author)
- Lipotype GmbH
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- Klose, Christian (author)
- Lipotype GmbH
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- Heinze, Georg (author)
- Medical University of Vienna
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- Reindl-Schwaighofer, Roman (author)
- Medical University of Vienna
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- Hu, Karin (author)
- Medical University of Vienna
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- Perco, Paul (author)
- Medical University of Innsbruck
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- Eder, Susanne (author)
- Medical University of Innsbruck
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- Rosivall, Laszlo (author)
- Semmelweis University
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- Mark, Patrick B. (author)
- University of Glasgow
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- Ju, Wenjun (author)
- University of Michigan
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- Kretzler, Matthias (author)
- University of Michigan
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- McCarthy, Mark I. (author)
- University of Oxford,Wellcome Trust Centre for Human Genetics
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- Heerspink, Hiddo L. (author)
- University Medical Center Groningen
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- Wiecek, Andrzej (author)
- Medical University of Silesia
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- Gomez, Maria F. (author)
- Lund University,Lunds universitet,Diabetiska komplikationer,Forskargrupper vid Lunds universitet,Diabetic Complications,Lund University Research Groups
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- Oberbauer, Rainer (author)
- Medical University of Vienna
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(creator_code:org_t)
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- Elsevier BV, 2019
- 2019
- English.
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In: Kidney International. - : Elsevier BV. - 0085-2538. ; 96:6, s. 1381-1388
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http://dx.doi.org/10...
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Abstract
Subject headings
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- Clinical risk factors explain only a fraction of the variability of estimated glomerular filtration rate (eGFR) decline in people with type 2 diabetes. Cross-omics technologies by virtue of a wide spectrum screening of plasma samples have the potential to identify biomarkers for the refinement of prognosis in addition to clinical variables. Here we utilized proteomics, metabolomics and lipidomics panel assay measurements in baseline plasma samples from the multinational PROVALID study (PROspective cohort study in patients with type 2 diabetes mellitus for VALIDation of biomarkers) of patients with incident or early chronic kidney disease (median follow-up 35 months, median baseline eGFR 84 mL/min/1.73 m2, urine albumin-to-creatinine ratio 8.1 mg/g). In an accelerated case-control study, 258 individuals with a stable eGFR course (median eGFR change 0.1 mL/min/year) were compared to 223 individuals with a rapid eGFR decline (median eGFR decline -6.75 mL/min/year) using Bayesian multivariable logistic regression models to assess the discrimination of eGFR trajectories. The analysis included 402 candidate predictors and showed two protein markers (KIM-1, NTproBNP) to be relevant predictors of the eGFR trajectory with baseline eGFR being an important clinical covariate. The inclusion of metabolomic and lipidomic platforms did not improve discrimination substantially. Predictions using all available variables were statistically indistinguishable from predictions using only KIM-1 and baseline eGFR (area under the receiver operating characteristic curve 0.63). Thus, the discrimination of eGFR trajectories in patients with incident or early diabetic kidney disease and maintained baseline eGFR was modest and the protein marker KIM-1 was the most important predictor.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- biomarkers
- chronic kidney disease
- integrative analysis
- multiomics
- prognosis
- type 2 diabetes
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Kammer, Michael
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Heinzel, Andreas
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Willency, Jill A ...
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Duffin, Kevin L.
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Mayer, Gert
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Simons, Kai
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show more...
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Gerl, Mathias J.
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Klose, Christian
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Heinze, Georg
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Reindl-Schwaigho ...
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Hu, Karin
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Perco, Paul
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Eder, Susanne
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Rosivall, Laszlo
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Mark, Patrick B.
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Ju, Wenjun
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Kretzler, Matthi ...
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McCarthy, Mark I ...
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Heerspink, Hiddo ...
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Wiecek, Andrzej
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Gomez, Maria F.
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Oberbauer, Raine ...
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Urology and Neph ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
- Articles in the publication
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Kidney Internati ...
- By the university
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Lund University