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Effect of high-dose...
Effect of high-dose vitamin A supplementation on the immune response to Bacille Calmette-Guerin vaccines
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Diness, Birgitte R. (författare)
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Fisker, Ane B. (författare)
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- Roth, Adam (författare)
- Lund University,Lunds universitet,Klinisk mikrobiologi, Malmö,Forskargrupper vid Lunds universitet,Clinical Microbiology, Malmö,Lund University Research Groups
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Yazdanbakhsh, Maria (författare)
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Sartono, Erliyani (författare)
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Whittle, Hilton (författare)
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Nante, Jose E. (författare)
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Lisse, Ida M. (författare)
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Ravn, Henrik (författare)
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Rodrigues, Amabelia (författare)
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Aaby, Peter (författare)
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Benn, Christine S. (författare)
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(creator_code:org_t)
- 2007
- 2007
- Engelska.
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Ingår i: American Journal of Clinical Nutrition. - 1938-3207. ; 86:4, s. 1152-1159
- Relaterad länk:
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http://www.ajcn.org/... (free)
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Background: Vitamin A supplementation (VAS) at birth has been associated with decreased mortality in Asia. Bacille Calmette-Guerin (BCG) vaccine is given at birth in tuberculosis-endemic countries. Previous studies suggest that VAS may influence the immune response to vaccines. Objective: Our objective was to examine whether VAS influences the immune response to simultaneously administered BCG vaccine. Design: Within a randomized trial of 50 000 IU vitamin A or placebo Given with BCG vaccine at birth in Guinea-Bissau, 27 10 infants were examined for BCG scar formation and delayed-type hypersensitivity (DTH) to purified protein derivative of Mycobacterium tuberculosis (PPD) at 2 and 6 mo of age. The ex vivo cytokine response to PPD was measured in 607 infants. Results: At 2 mo of age, 39% (43% of the boys and 34% of the girls) responded to PPD. The prevalence ratio of a measurable PPD reaction for VAS compared with placebo recipients was 0.90 (95% CI: 0.80, 1.02) for all infants. 0.81 (95% CI: 0.69, 0.95) for boys, and 1.04 (95% CI: 0.86, 1.26) for girls. At 6 mo of age, 42% of the infants responded to PPD. No difference was observed between VAS and placebo recipients. The prevalence of BCG scar was not affected by VAS. The ex vivo interferon-gamma response to PPD was increased by VAS (means ratio: 1.40: 95% CI: 1.03, 1.91). Conclusions: VAS with BCG vaccination does not appear to interfere with the long-term immune response to BCG. However, VAS temporarily altered the DTH reaction to PPD in boys at 2 mo of age, suggesting sex differences in the immunologic response to VAS Given with BCG. This trial was registered at www.clinicaltrials.gov as #NCT00168597.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Näringslära (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Nutrition and Dietetics (hsv//eng)
Nyckelord
- BCG vaccination
- Bacille Calmette-Guerin
- vitamin A
- purified protein derivative of Mycobacterium tuberculosis response
- PPD response
- sex-differential effects
- randomized trial
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- art (ämneskategori)
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- Av författaren/redakt...
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Diness, Birgitte ...
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Fisker, Ane B.
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Roth, Adam
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Yazdanbakhsh, Ma ...
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Sartono, Erliyan ...
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Whittle, Hilton
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visa fler...
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Nante, Jose E.
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Lisse, Ida M.
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Ravn, Henrik
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Rodrigues, Amabe ...
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Aaby, Peter
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Benn, Christine ...
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visa färre...
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