Sökning: onr:"swepub:oai:lup.lub.lu.se:c27238c3-0e72-4834-824b-4c68facd4d66" >
Long-Term Risk of C...
-
Inghammar, MalinLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Danish Serum Institute, Copenhagen,Skåne University Hospital
(författare)
Long-Term Risk of Cardiovascular Death with Use of Clarithromycin and Roxithromycin : A Nationwide Cohort Study
- Artikel/kapitelEngelska2018
Förlag, utgivningsår, omfång ...
-
2017-11-16
-
Oxford University Press (OUP),2018
-
9 s.
Nummerbeteckningar
-
LIBRIS-ID:oai:lup.lub.lu.se:c27238c3-0e72-4834-824b-4c68facd4d66
-
https://lup.lub.lu.se/record/c27238c3-0e72-4834-824b-4c68facd4d66URI
-
https://doi.org/10.1093/aje/kwx359DOI
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:137905821URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:for swepub-publicationtype
-
Ämneskategori:ref swepub-contenttype
Anmärkningar
-
Recent studies have raised concern that macrolide antibiotics may be associated with an increased long-term risk of cardiovascular death. We examined the 1-year risk associated with treatment with clarithromycin (n = 187,887) or roxithromycin (n = 698,899) compared with penicillin V (n = 3,473,081) matched 1:4 on propensity score, in a nationwide, registry-based cohort study in Danish outpatients, 1997-2011. Among clarithromycin courses, the rate ratio for cardiovascular death was 1.24 (95% confidence interval (CI): 0.96, 1.59). Among roxithromycin courses, the rate ratio was 0.99 (95% CI: 0.86, 1.16). In analyses by time after treatment start, the rate ratio associated with clarithromycin was 1.66 (95% CI: 0.98, 2.79) during days 0-7. This was attenuated in later time periods (days 8-89, rate ratio = 1.30, 95% CI: 0.88, 1.94; and days 90-364, rate ratio = 0.96, 95% CI: 0.63, 1.47). For roxithromycin, the rate ratios were 0.88 (95% CI: 0.59, 1.32) during days 0-7, 1.17 (95% CI: 0.92, 1.48) during days 8-89, and 0.88 (95% CI: 0.70, 1.10) during days 90-364. We found no increased risk of cardiovascular death in a general outpatient population. With clarithromycin, we observed a transient increased risk during days 0-7 after treatment start, which corresponds to the period of active treatment. This association was absent in later time periods, which is consistent with no long-term toxicity resulting in cardiovascular death.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Nibell, OlofLund University,Lunds universitet,Infektionsmedicin,Sektion III,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Infection Medicine (BMC),Section III,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital,Danish Serum Institute, Copenhagen(Swepub:lu)med-onb
(författare)
-
Pasternak, BjörnKarolinska Institutet,Karolinska Institute,Danish Serum Institute, Copenhagen(Swepub:lu)extLU-33
(författare)
-
Melbye, MadsStanford University,Danish Serum Institute, Copenhagen
(författare)
-
Svanström, HenrikDanish Serum Institute, Copenhagen
(författare)
-
Hviid, AndersDanish Serum Institute, Copenhagen
(författare)
-
InfektionsmedicinSektion III
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:American Journal of Epidemiology: Oxford University Press (OUP)187:4, s. 777-7850002-92621476-6256
Internetlänk
Hitta via bibliotek
Till lärosätets databas