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Krebs von den Lunge...
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Stockhammer, PaulRuhrlandklinik
(författare)
Krebs von den Lungen 6 (KL-6) is a novel diagnostic and prognostic biomarker in pleural mesothelioma
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:c365e068-ffe7-4da6-84bb-f3ba3e729621
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https://lup.lub.lu.se/record/c365e068-ffe7-4da6-84bb-f3ba3e729621URI
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https://doi.org/10.1016/j.lungcan.2023.107360DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Objectives: Pleural mesothelioma (PM) is a rare disease with dismal outcome. Systemic treatment options include chemotherapy and immunotherapy, but biomarkers for treatment personalization are missing. The only FDA-approved diagnostic biomarker is the soluble mesothelin-related protein (SMRP). Krebs von den Lungen-6 (KL-6) is a human mucin 1 (MUC1) glycoprotein, which has shown diagnostic and prognostic value as a biomarker in other malignancies. The present study investigated whether KL-6 can serve as a diagnostic and/or prognostic biomarker in PM. Materials and methods: Using a fully-automated chemiluminescence enzyme immunoassay (CLEIA) for KL-6 and SMRP, pleural effusion samples from 87 consecutive patients with PM and 25 patients with non-malignant pleural disorders were studied. In addition, KL-6 and SMRP levels were determined in corresponding patient sera, and in an independent validation cohort (n = 122). MUC1 mRNA and protein expression, and KL-6 levels in cell line supernatants were investigated in PM primary cell lines in vitro. Results: PM patients had significantly higher KL-6 levels in pleural effusion than non-malignant controls (AUC 0.78, p < 0.0001). Among PM patients, levels were highest in those with epithelioid or biphasic histologies. There was a strong positive correlation between pleural effusion levels of KL-6 and SMRP (p < 0.0001). KL-6 levels in sera similarly associated with diagnosis of PM, however, to a lesser extent (AUC 0.71, p = 0.008). PM patients with high pleural effusion KL-6 levels (≥303 IU/mL) had significantly better overall survival (OS) compared to those with low KL-6 levels (HR 0.51, p = 0.004). Congruently, high tumor cell MUC1 mRNA expression in primary cell lines associated with prolonged corresponding patient OS (HR 0.35, p = 0.004). These findings were confirmed in an independent validation cohort. Conclusion: This is the first study demonstrating KL-6 as a potential novel liquid-based diagnostic and prognostic biomarker in PM.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Baumeister, HannahRuhrlandklinik
(författare)
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Ploenes, TillRuhrlandklinik
(författare)
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Bonella, FrancescoRuhrlandklinik
(författare)
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Theegarten, DirkUniversity Hospital Essen
(författare)
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Dome, BalazsLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups,Semmelweis University,National Korányi Institute for Tuberculosis and Pulmonology, Hungary,Medical University of Vienna(Swepub:lu)ba1464do
(författare)
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Pirker, ChristineMedical University of Vienna
(författare)
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Berger, WalterMedical University of Vienna
(författare)
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Hegedüs, LucaRuhrlandklinik
(författare)
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Baranyi, MarcellSemmelweis University
(författare)
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Schuler, MartinUniversity Hospital Essen
(författare)
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Deshayes, SophieUniversity of Nantes
(författare)
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Bölükbas, ServetRuhrlandklinik
(författare)
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Aigner, ClemensUniversity Hospital Essen,Ruhrlandklinik
(författare)
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Blanquart, ChristopheUniversity of Nantes
(författare)
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Hegedüs, BalazsRuhrlandklinik
(författare)
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RuhrlandklinikUniversity Hospital Essen
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Lung Cancer1850169-5002
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Stockhammer, Pau ...
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Baumeister, Hann ...
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Ploenes, Till
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Bonella, Frances ...
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Theegarten, Dirk
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Dome, Balazs
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visa fler...
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Pirker, Christin ...
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Berger, Walter
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Hegedüs, Luca
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Baranyi, Marcell
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Schuler, Martin
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Deshayes, Sophie
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Bölükbas, Servet
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Aigner, Clemens
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Blanquart, Chris ...
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Hegedüs, Balazs
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Klinisk laborato ...
- Artiklar i publikationen
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Lung Cancer
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Lunds universitet