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A trans-omics asses...
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Chen, JiajinNanjing Medical University
(författare)
A trans-omics assessment of gene–gene interaction in early-stage NSCLC
- Artikel/kapitelEngelska2023
Förlag, utgivningsår, omfång ...
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2022-12-05
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Wiley,2023
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15 s.
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:cc43223f-c21f-48c0-99d6-2a06a5be2c76
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https://lup.lub.lu.se/record/cc43223f-c21f-48c0-99d6-2a06a5be2c76URI
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https://doi.org/10.1002/1878-0261.13345DOI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Epigenome-wide gene–gene (G × G) interactions associated with non-small-cell lung cancer (NSCLC) survival may provide insights into molecular mechanisms and therapeutic targets. Hence, we proposed a three-step analytic strategy to identify significant and robust G × G interactions that are relevant to NSCLC survival. In the first step, among 49 billion pairs of DNA methylation probes, we identified 175 775 G × G interactions with PBonferroni ≤ 0.05 in the discovery phase of epigenomic analysis; among them, 15 534 were confirmed with P ≤ 0.05 in the validation phase. In the second step, we further performed a functional validation for these G × G interactions at the gene expression level by way of a two-phase (discovery and validation) transcriptomic analysis, and confirmed 25 significant G × G interactions enriched in the 6p21.33 and 6p22.1 regions. In the third step, we identified two G × G interactions using the trans-omics analysis, which had significant (P ≤ 0.05) epigenetic cis-regulation of transcription and robust G × G interactions at both the epigenetic and transcriptional levels. These interactions were cg14391855 × cg23937960 (βinteraction = 0.018, P = 1.87 × 10−12), which mapped to RELA × HLA-G (βinteraction = 0.218, P = 8.82 × 10−11) and cg08872738 × cg27077312 (βinteraction = −0.010, P = 1.16 × 10−11), which mapped to TUBA1B × TOMM40 (βinteraction =−0.250, P = 3.83 × 10−10). A trans-omics mediation analysis revealed that 20.3% of epigenetic effects on NSCLC survival were significantly (P = 0.034) mediated through transcriptional expression. These statistically significant trans-omics G × G interactions can also discriminate patients with high risk of mortality. In summary, we identified two G × G interactions at both the epigenetic and transcriptional levels, and our findings may provide potential clues for precision treatment of NSCLC.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Song, YunjieNanjing Medical University
(författare)
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Li, YiUniversity of Michigan
(författare)
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Wei, YongyueNanjing Medical University,Harvard University
(författare)
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Shen, SipengNanjing Medical University
(författare)
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Zhao, YangNanjing Medical University
(författare)
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You, DongfangNanjing Medical University
(författare)
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Su, LiMassachusetts General Hospital,Harvard University
(författare)
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Bjaanæs, Maria MoksnesOslo university hospital
(författare)
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Karlsson, AnnaLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund(Swepub:lu)med-akn
(författare)
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Planck, MariaLund University,Lunds universitet,Lungmedicin, allergologi och palliativ medicin,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Respiratory Medicine, Allergology, and Palliative Medicine,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund(Swepub:lu)onk-mpl
(författare)
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Staaf, JohanLund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund(Swepub:lu)onk-jst
(författare)
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Helland, ÅslaugUniversity of Oslo,Oslo university hospital
(författare)
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Esteller, ManelUniversity of Barcelona,Josep Carreras Leukaemia Research Institute (IJC),Catalan Institution for Research and Advanced Studies
(författare)
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Shen, HongbingNanjing Medical University
(författare)
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Christiani, David C.Massachusetts General Hospital,Harvard University
(författare)
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Zhang, RuyangHarvard University,Nanjing Medical University
(författare)
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Chen, FengNanjing Medical University
(författare)
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Nanjing Medical UniversityUniversity of Michigan
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Molecular Oncology: Wiley17:1, s. 173-1871574-78911878-0261
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Till lärosätets databas
- Av författaren/redakt...
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Chen, Jiajin
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Song, Yunjie
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Li, Yi
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Wei, Yongyue
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Shen, Sipeng
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Zhao, Yang
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visa fler...
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You, Dongfang
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Su, Li
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Bjaanæs, Maria M ...
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Karlsson, Anna
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Planck, Maria
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Staaf, Johan
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Helland, Åslaug
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Esteller, Manel
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Shen, Hongbing
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Christiani, Davi ...
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Zhang, Ruyang
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Chen, Feng
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Cancer och onkol ...
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Molecular Oncolo ...
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Lunds universitet