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RIC3 variants are n...
RIC3 variants are not associated with Parkinson's disease in large European, Latin American, or East Asian cohorts
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- Brolin, Kajsa (author)
- Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups
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- Bandres-Ciga, Sara (author)
- National Institutes of Health, United States
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- Leonard, Hampton (author)
- National Institutes of Health, United States
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- Makarious, Mary B. (author)
- National Institutes of Health, United States
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- Blauwendraat, Cornelis (author)
- National Institutes of Health, United States
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- Mata, Ignacio F. (author)
- Cleveland Clinic Foundation
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- Foo, Jia Nee (author)
- Nanyang Technological University
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- Pihlstrøm, Lasse (author)
- Oslo university hospital
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- Swanberg, Maria (author)
- Lund University,Lunds universitet,Translationell Neurogenetik,Forskargrupper vid Lunds universitet,Translational Neurogenetics,Lund University Research Groups
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- Gan-Or, Ziv (author)
- McGill University
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- Tan, Manuela MX (author)
- Oslo university hospital
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(creator_code:org_t)
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- Elsevier BV, 2022
- 2022
- English.
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In: Neurobiology of Aging. - : Elsevier BV. - 0197-4580. ; 109, s. 264-268
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Abstract
Subject headings
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- Parkinson's disease (PD) is a complex neurodegenerative disorder in which both rare and common genetic variants contribute to disease risk. Multiple genes have been reported to be linked to monogenic PD but these only explain a fraction of the observed familial aggregation. Rare variants in RIC3 have been suggested to be associated with PD in the Indian population. However, replication studies yielded inconsistent results. We further investigate the role of RIC3 variants in PD in European cohorts using individual-level genotyping data from 14,671 PD patients and 17,667 controls, as well as whole-genome sequencing data from 1,615 patients and 961 controls. We also investigated RIC3 using summary statistics from a Latin American cohort of 1,481 individuals, and from a cohort of 31,575 individuals of East Asian ancestry. We did not identify any association between RIC3 and PD in any of the cohorts. However, more studies of rare variants in non-European ancestry populations, in particular South Asian populations, are necessary to further evaluate the world-wide role of RIC3 in PD etiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
Keyword
- Genetics
- Parkinson's disease
- RIC3
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Brolin, Kajsa
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Bandres-Ciga, Sa ...
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Leonard, Hampton
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Makarious, Mary ...
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Blauwendraat, Co ...
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Mata, Ignacio F.
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show more...
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Foo, Jia Nee
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Pihlstrøm, Lasse
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Swanberg, Maria
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Gan-Or, Ziv
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Tan, Manuela MX
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
- Articles in the publication
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Neurobiology of ...
- By the university
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Lund University