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Circulating pro-neu...
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Barchetta, IlariaSapienza University of Rome
(författare)
Circulating pro-neurotensin levels predict bodyweight gain and metabolic alterations in children
- Artikel/kapitelEngelska2021
Förlag, utgivningsår, omfång ...
Nummerbeteckningar
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LIBRIS-ID:oai:lup.lub.lu.se:da046f46-3236-4527-9683-c3df609e5054
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https://lup.lub.lu.se/record/da046f46-3236-4527-9683-c3df609e5054URI
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https://doi.org/10.1016/j.numecd.2020.11.025DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:art swepub-publicationtype
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Ämneskategori:ref swepub-contenttype
Anmärkningar
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Background and aims: Neurotensin (NT) is an intestinal peptide released after fat ingestion, which regulates appetite and facilitates lipid absorption. Elevated plasma levels of its stable precursor pro-neurotensin (pro-NT) are associated with type 2 diabetes, obesity and cardiovascular mortality in adult populations; no data on pro-NT and metabolic disease are available in children. Aim of the study was to evaluate plasma pro-NT in relation to the presence of obesity in children, and to test if high pro-NT associates with the development of metabolic impairment later in life. Methods and results: For this longitudinal retrospective study, we studied 151 overweight/obese children undergoing metabolic evaluations at University of Cagliari, Italy. Pro-NT was also assessed in 46 normal-weight, age-, sex-comparable normal-weight children, selected as a reference group. At the baseline, pro-NT was comparable between overweight/obese and normal-weight children and correlated positively with age (p < 0.001), triglycerides (p < 0.001) and inversely with HDL levels (p = 0.008). Plasma pro-NT associated with high triglycerides with OR = 5.9 (95%CI: 1.24–28.1; p = 0.026) after adjustment for multiple confounders. At the 6.5-year follow-up, high basal pro-NT associated with impaired β-cell function to compensate for insulin-resistance (disposition index: r = −0.19, p = 0.035) and predicted bodyweight increase, as indicated by percentage change of standard deviation score BMI (median(95%CI) = +20.8(+4.9-+27.5)% in the highest tertile), independently from age, sex, triglycerides and insulin-resistance (standardized β = 0.24; p = 0.036). Conclusions: Elevated pro-NT levels in children are significantly associated with weight gain later in life and may represent a marker of susceptibility to metabolic impairment in presence of obesity.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Bertoccini, LauraSapienza University of Rome
(författare)
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Sentinelli, FedericaSapienza University of Rome,University of L'Aquila
(författare)
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Bailetti, DiegoSapienza University of Rome,University of L'Aquila
(författare)
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Marini, GiacomoUniversity of Cagliari
(författare)
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Cimini, Flavia AgataSapienza University of Rome
(författare)
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Ceccarelli, ValentinaSapienza University of Rome
(författare)
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Struck, JoachimSphingotec GmbH
(författare)
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Schulte, JaninSphingotec GmbH
(författare)
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Loche, SandroRegional Hospital For Microcitemia
(författare)
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Cossu, EfisioUniversity of Cagliari
(författare)
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Melander, OlleLund University,Lunds universitet,Kardiovaskulär forskning - hypertoni,Forskargrupper vid Lunds universitet,Cardiovascular Research - Hypertension,Lund University Research Groups,Skåne University Hospital(Swepub:lu)endo-ome
(författare)
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Cavallo, Maria G.Sapienza University of Rome
(författare)
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Baroni, Marco G.University of L'Aquila,Istituto Neurologico Mediterraneo Neuromed
(författare)
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Sapienza University of RomeUniversity of L'Aquila
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Nutrition, Metabolism and Cardiovascular Diseases: Elsevier BV31:3, s. 902-9100939-4753
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Barchetta, Ilari ...
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Bertoccini, Laur ...
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Sentinelli, Fede ...
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Bailetti, Diego
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Marini, Giacomo
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Cimini, Flavia A ...
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visa fler...
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Ceccarelli, Vale ...
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Struck, Joachim
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Schulte, Janin
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Loche, Sandro
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Cossu, Efisio
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Melander, Olle
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Cavallo, Maria G ...
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Baroni, Marco G.
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- MEDICIN OCH HÄLSOVETENSKAP
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Nutrition, Metab ...
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Lunds universitet