Sökning: onr:"swepub:oai:lup.lub.lu.se:eebf59c1-4526-4298-81e3-e07e1379f749" > Serum aromatic and ...
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000 | 04630naa a2200529 4500 | |
001 | oai:lup.lub.lu.se:eebf59c1-4526-4298-81e3-e07e1379f749 | |
003 | SwePub | |
008 | 210111s2021 | |||||||||||000 ||eng| | |
024 | 7 | a https://lup.lub.lu.se/record/eebf59c1-4526-4298-81e3-e07e1379f7492 URI |
024 | 7 | a https://doi.org/10.1111/liv.147432 DOI |
040 | a (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a de Mello, Vanessa D.u University of Eastern Finland4 aut |
245 | 1 0 | a Serum aromatic and branched-chain amino acids associated with NASH demonstrate divergent associations with serum lipids |
264 | c 2020-12-05 | |
264 | 1 | b Wiley,c 2021 |
520 | a Background & Aims: Non-alcoholic fatty liver disease (NAFLD) has been associated with multiple metabolic abnormalities. By applying a non-targeted metabolomics approach, we aimed at investigating whether serum metabolite profile that associates with NAFLD would differ in its association with NAFLD-related metabolic risk factors. Methods & Results: A total of 233 subjects (mean ± SD: 48.3 ± 9.3 years old; BMI: 43.1 ± 5.4 kg/m2; 64 male) undergoing bariatric surgery were studied. Of these participants, 164 with liver histology could be classified as normal liver (n = 79), simple steatosis (SS, n = 40) or non-alcoholic steatohepatitis (NASH, n = 45). Among the identified fasting serum metabolites with higher levels in those with NASH when compared to those with normal phenotype were the aromatic amino acids (AAAs: tryptophan, tyrosine and phenylalanine), the branched-chain amino acids (BCAAs: leucine and isoleucine), a phosphatidylcholine (PC(16:0/16:1)) and uridine (all FDRp < 0.05). Only tryptophan was significantly higher in those with NASH compared to those with SS (FDRp < 0.05). Only the AAAs tryptophan and tyrosine correlated positively with serum total and LDL cholesterol (FDRp < 0.1), and accordingly, with liver LDLR at mRNA expression level. In addition, tryptophan was the single AA associated with liver DNA methylation of CpG sites known to be differentially methylated in those with NASH. Conclusions: We found that serum levels of the NASH-related AAAs and BCAAs demonstrate divergent associations with serum lipids. The specific correlation of tryptophan with LDL-c may result from the molecular events affecting LDLR mRNA expression and NASH-associated methylation of genes in the liver. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
653 | a aromatic amino acids | |
653 | a DNA methylation | |
653 | a epigenetics | |
653 | a LDL cholesterol | |
653 | a NAFLD | |
653 | a NASH | |
653 | a non-targeted metabolomics | |
653 | a tryptophan | |
700 | 1 | a Sehgal, Ratikau University of Eastern Finland4 aut |
700 | 1 | a Männistö, Villeu University of Eastern Finland4 aut |
700 | 1 | a Klåvus, Antonu University of Eastern Finland4 aut |
700 | 1 | a Nilsson, Emma Au Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-eca |
700 | 1 | a Perfilyev, Alexanderu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)med-apy |
700 | 1 | a Kaminska, Dorotau University of Eastern Finland4 aut |
700 | 1 | a Miao, Zongu University of California, Los Angeles4 aut |
700 | 1 | a Pajukanta, Päiviu University of California, Los Angeles4 aut |
700 | 1 | a Ling, Charlotteu Lund University,Lunds universitet,Diabetes - epigenetik,Forskargrupper vid Lunds universitet,Diabetes - Epigenetics,Lund University Research Groups4 aut0 (Swepub:lu)endo-cl0 |
700 | 1 | a Hanhineva, Katiu University of Eastern Finland,University of Turku4 aut |
700 | 1 | a Pihlajamäki, Jussiu Kuopio University Hospital,University of Eastern Finland4 aut |
710 | 2 | a University of Eastern Finlandb Diabetes - epigenetik4 org |
773 | 0 | t Liver Internationald : Wileyg 41:4, s. 754-763q 41:4<754-763x 1478-3223x 1478-3231 |
856 | 4 | u http://dx.doi.org/10.1111/liv.14743x freey FULLTEXT |
856 | 4 | u https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/liv.14743 |
856 | 4 8 | u https://lup.lub.lu.se/record/eebf59c1-4526-4298-81e3-e07e1379f749 |
856 | 4 8 | u https://doi.org/10.1111/liv.14743 |
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