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  • Kjær, MetteFinnmark Hospital Trust,University Hospital of North Norway (author)

Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia : a systematic review

  • Article/chapterEnglish2019

Publisher, publication year, extent ...

  • 2018-11-22
  • Wiley,2019

Numbers

  • LIBRIS-ID:oai:lup.lub.lu.se:f340ac11-2615-4a4d-9e80-5e8dabc7ac57
  • https://lup.lub.lu.se/record/f340ac11-2615-4a4d-9e80-5e8dabc7ac57URI
  • https://doi.org/10.1111/vox.12725DOI

Supplementary language notes

  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Background and Objectives: In Caucasians, fetal/neonatal alloimmune thrombocytopenia (FNAIT) is most commonly due to maternal HPA-1a antibodies. HPA-1a typing followed by screening for anti-HPA-1a antibodies in HPA-1bb women may identify first pregnancies at risk. Our goal was to review results from previous published studies to examine whether the maternal antibody level to HPA-1a could be used to identify high-risk pregnancies. Materials and Methods: The studies included were categorized by recruitment strategies: screening of unselected pregnancies or samples analyzed from known or suspected FNAIT patients. Results: Three prospective studies reported results from screening programmes, and 10 retrospective studies focused on suspected cases of FNAIT. In 8 studies samples for antibody measurement, performed by the monoclonal antibody immobilization of platelet antigen (MAIPA) assay, and samples for determining fetal/neonatal platelet count were collected simultaneously. In these 8 studies, the maternal antibody level correlated with the risk of severe thrombocytopenia. The prospective studies reported high negative predictive values (88–95%), which would allow for the use of maternal anti-HPA-1a antibody level as a predictive tool in a screening setting, in order to identify cases at low risk for FNAIT. However, due to low positive predictive values reported in prospective as well as retrospective studies (54–97%), the maternal antibody level is less suited for the final diagnosis and for guiding antenatal treatment. Conclusion: HPA-1a antibody level has the potential to predict the severity of FNAIT.

Subject headings and genre

Added entries (persons, corporate bodies, meetings, titles ...)

  • Bertrand, GeraldFrench Blood Services of Brittany (author)
  • Bakchoul, TamamUniversity of Tübingen,University Hospital Greifswald (author)
  • Massey, EdwinInternational Blood Group Reference Laboratory (author)
  • Baker, Jillian M.Hospital for Sick Children, Toronto (author)
  • Lieberman, LaniUniversity of Toronto (author)
  • Tanael, SusanoCanadian Blood Services (author)
  • Greinacher, AndreasUniversity Hospital Greifswald (author)
  • Murphy, Michael F.University of Oxford (author)
  • Arnold, Donald M.McMaster University (author)
  • Baidya, ShomaAustralian Red Cross Blood Service (author)
  • Bussel, JamesWeill Cornell Medical College (author)
  • Hume, HeatherCentre Hospitalier Universitaire Sainte-Justine (author)
  • Kaplan, CécileInstitut National de la Transfusion Sanguine (INTS) (author)
  • Oepkes, DickLeiden University Medical Centre (author)
  • Ryan, GregMount Sinai Hospital of University of Toronto (author)
  • Savoia, HelenRoyal Children's Hospital, Melbourne (author)
  • Shehata, NadineMount Sinai Hospital of University of Toronto,Canadian Blood Services (author)
  • Kjeldsen-Kragh, JensLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Regional Laboratories Region Skåne,University Hospital of North Norway(Swepub:lu)med-jks (author)
  • Finnmark Hospital TrustUniversity Hospital of North Norway (creator_code:org_t)
  • International Collaboration for Transfusion Medicine Guidelines

Related titles

  • In:Vox Sanguinis: Wiley114:1, s. 79-940042-9007

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