Search: onr:"swepub:oai:lup.lub.lu.se:f340ac11-2615-4a4d-9e80-5e8dabc7ac57" >
Maternal HPA-1a ant...
-
Kjær, MetteFinnmark Hospital Trust,University Hospital of North Norway
(author)
Maternal HPA-1a antibody level and its role in predicting the severity of Fetal/Neonatal Alloimmune Thrombocytopenia : a systematic review
- Article/chapterEnglish2019
Publisher, publication year, extent ...
Numbers
-
LIBRIS-ID:oai:lup.lub.lu.se:f340ac11-2615-4a4d-9e80-5e8dabc7ac57
-
https://lup.lub.lu.se/record/f340ac11-2615-4a4d-9e80-5e8dabc7ac57URI
-
https://doi.org/10.1111/vox.12725DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:art swepub-publicationtype
-
Subject category:ref swepub-contenttype
Notes
-
Background and Objectives: In Caucasians, fetal/neonatal alloimmune thrombocytopenia (FNAIT) is most commonly due to maternal HPA-1a antibodies. HPA-1a typing followed by screening for anti-HPA-1a antibodies in HPA-1bb women may identify first pregnancies at risk. Our goal was to review results from previous published studies to examine whether the maternal antibody level to HPA-1a could be used to identify high-risk pregnancies. Materials and Methods: The studies included were categorized by recruitment strategies: screening of unselected pregnancies or samples analyzed from known or suspected FNAIT patients. Results: Three prospective studies reported results from screening programmes, and 10 retrospective studies focused on suspected cases of FNAIT. In 8 studies samples for antibody measurement, performed by the monoclonal antibody immobilization of platelet antigen (MAIPA) assay, and samples for determining fetal/neonatal platelet count were collected simultaneously. In these 8 studies, the maternal antibody level correlated with the risk of severe thrombocytopenia. The prospective studies reported high negative predictive values (88–95%), which would allow for the use of maternal anti-HPA-1a antibody level as a predictive tool in a screening setting, in order to identify cases at low risk for FNAIT. However, due to low positive predictive values reported in prospective as well as retrospective studies (54–97%), the maternal antibody level is less suited for the final diagnosis and for guiding antenatal treatment. Conclusion: HPA-1a antibody level has the potential to predict the severity of FNAIT.
Subject headings and genre
Added entries (persons, corporate bodies, meetings, titles ...)
-
Bertrand, GeraldFrench Blood Services of Brittany
(author)
-
Bakchoul, TamamUniversity of Tübingen,University Hospital Greifswald
(author)
-
Massey, EdwinInternational Blood Group Reference Laboratory
(author)
-
Baker, Jillian M.Hospital for Sick Children, Toronto
(author)
-
Lieberman, LaniUniversity of Toronto
(author)
-
Tanael, SusanoCanadian Blood Services
(author)
-
Greinacher, AndreasUniversity Hospital Greifswald
(author)
-
Murphy, Michael F.University of Oxford
(author)
-
Arnold, Donald M.McMaster University
(author)
-
Baidya, ShomaAustralian Red Cross Blood Service
(author)
-
Bussel, JamesWeill Cornell Medical College
(author)
-
Hume, HeatherCentre Hospitalier Universitaire Sainte-Justine
(author)
-
Kaplan, CécileInstitut National de la Transfusion Sanguine (INTS)
(author)
-
Oepkes, DickLeiden University Medical Centre
(author)
-
Ryan, GregMount Sinai Hospital of University of Toronto
(author)
-
Savoia, HelenRoyal Children's Hospital, Melbourne
(author)
-
Shehata, NadineMount Sinai Hospital of University of Toronto,Canadian Blood Services
(author)
-
Kjeldsen-Kragh, JensLund University,Lunds universitet,Avdelningen för hematologi och transfusionsmedicin,Institutionen för laboratoriemedicin,Medicinska fakulteten,Division of Hematology and Transfusion Medicine,Department of Laboratory Medicine,Faculty of Medicine,Regional Laboratories Region Skåne,University Hospital of North Norway(Swepub:lu)med-jks
(author)
-
Finnmark Hospital TrustUniversity Hospital of North Norway
(creator_code:org_t)
-
International Collaboration for Transfusion Medicine Guidelines
Related titles
-
In:Vox Sanguinis: Wiley114:1, s. 79-940042-9007
Internet link
Find in a library
To the university's database
- By the author/editor
-
Kjær, Mette
-
Bertrand, Gerald
-
Bakchoul, Tamam
-
Massey, Edwin
-
Baker, Jillian M ...
-
Lieberman, Lani
-
show more...
-
Tanael, Susano
-
Greinacher, Andr ...
-
Murphy, Michael ...
-
Arnold, Donald M ...
-
Baidya, Shoma
-
Bussel, James
-
Hume, Heather
-
Kaplan, Cécile
-
Oepkes, Dick
-
Ryan, Greg
-
Savoia, Helen
-
Shehata, Nadine
-
Kjeldsen-Kragh, ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Hematology
- Articles in the publication
-
Vox Sanguinis
- By the university
-
Lund University