C4b-binding protein (C4BP) activates B cells through the CD40 receptor

We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.

Angelini, F (author)
Bacharier, LB (author)
Blom, AnnaLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)klke-abl (author)
Mizoguchi, E (author)
Fujiwara, H (author)
Plebani, A (author)
Notarangelo, LD (author)
Dahlbäck, BjörnLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-bda (author)
Tsitsikov, E (author)
Geha, RS (author)
Institutionen för translationell medicinMedicinska fakulteten (creator_code:org_t)

By the author/editor: Brodeur, SR; Angelini, F; Bacharier, LB; Blom, Anna; Mizoguchi, E; Fujiwara, H; show more...; Plebani, A; Notarangelo, LD; Dahlbäck, Björn; Tsitsikov, E; Geha, RS; show less...

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MEDICAL AND HEALTH SCIENCES: MEDICAL AND HEAL ...; and Basic Medicine; and Immunology in th ...

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