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C4b-binding protein (C4BP) activates B cells through the CD40 receptor
- Article/chapterEnglish2003
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LIBRIS-ID:oai:lup.lub.lu.se:f8b64d40-ece0-4513-b242-003d3754cbaa
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https://lup.lub.lu.se/record/308125URI
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Language:English
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Summary in:English
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Subject category:art swepub-publicationtype
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Subject category:ref swepub-contenttype
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We demonstrate that the a. chain of human C4b binding protein (C4BP) binds directly to CD40 on human B cells at a site that differs from that used by CD40 ligand. C4BP induces proliferation, upregulation of CD54 and CD86 expression, and IL4-dependent IgE isotype switching in normal B cells but not in B cells from patients with CD40 or IKKgamma/NEMO deficiencies. Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation.
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Angelini, F
(author)
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Bacharier, LB
(author)
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Blom, AnnaLund University,Lunds universitet,Institutionen för translationell medicin,Medicinska fakulteten,Department of Translational Medicine,Faculty of Medicine(Swepub:lu)klke-abl
(author)
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Mizoguchi, E
(author)
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Fujiwara, H
(author)
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Plebani, A
(author)
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Notarangelo, LD
(author)
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Dahlbäck, BjörnLund University,Lunds universitet,Klinisk kemi, Malmö,Forskargrupper vid Lunds universitet,Clinical Chemistry, Malmö,Lund University Research Groups(Swepub:lu)klke-bda
(author)
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Tsitsikov, E
(author)
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Geha, RS
(author)
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Institutionen för translationell medicinMedicinska fakulteten
(creator_code:org_t)
Related titles
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In:Immunity18:6, s. 837-8481074-7613
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To the university's database
- By the author/editor
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Brodeur, SR
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Angelini, F
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Bacharier, LB
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Blom, Anna
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Mizoguchi, E
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Fujiwara, H
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show more...
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Plebani, A
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Notarangelo, LD
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Dahlbäck, Björn
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Tsitsikov, E
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Geha, RS
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Immunology in th ...
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Immunity
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Lund University