Sökning: onr:"swepub:oai:lup.lub.lu.se:fe22906b-6821-4428-99a8-851310dde0be" > A variant in FTO sh...
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000 | 06643naa a2201429 4500 | |
001 | oai:lup.lub.lu.se:fe22906b-6821-4428-99a8-851310dde0be | |
003 | SwePub | |
008 | 160401s2013 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:126492457 | |
024 | 7 | a https://lup.lub.lu.se/record/37489932 URI |
024 | 7 | a https://doi.org/10.1038/ng.25712 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1264924572 URI |
040 | a (SwePub)lud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Iles, Mark M.4 aut |
245 | 1 0 | a A variant in FTO shows association with melanoma risk not due to BMI |
264 | c 2013-03-03 | |
264 | 1 | b Springer Science and Business Media LLC,c 2013 |
520 | a We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 x 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanomasusceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Law, Matthew H.4 aut |
700 | 1 | a Stacey, Simon N.4 aut |
700 | 1 | a Han, Jiali4 aut |
700 | 1 | a Fang, Shenying4 aut |
700 | 1 | a Pfeiffer, Ruth4 aut |
700 | 1 | a Harland, Mark4 aut |
700 | 1 | a MacGregor, Stuart4 aut |
700 | 1 | a Taylor, John C.4 aut |
700 | 1 | a Aben, Katja K.4 aut |
700 | 1 | a Akslen, Lars A.4 aut |
700 | 1 | a Avril, Marie-Francoise4 aut |
700 | 1 | a Azizi, Esther4 aut |
700 | 1 | a Bakker, Bert4 aut |
700 | 1 | a Benediktsdottir, Kristrun R.4 aut |
700 | 1 | a Bergman, Wilma4 aut |
700 | 1 | a Scarra, Giovanna Bianchi4 aut |
700 | 1 | a Brown, Kevin M.4 aut |
700 | 1 | a Calista, Donato4 aut |
700 | 1 | a Chaudru, Valerie4 aut |
700 | 1 | a Fargnoli, Maria Concetta4 aut |
700 | 1 | a Cust, Anne E.4 aut |
700 | 1 | a Demenais, Florence4 aut |
700 | 1 | a Waal, Anne C. de4 aut |
700 | 1 | a Debniak, Tadeusz4 aut |
700 | 1 | a Elder, David E.4 aut |
700 | 1 | a Friedman, Eitan4 aut |
700 | 1 | a Galan, Pilar4 aut |
700 | 1 | a Ghiorzo, Paola4 aut |
700 | 1 | a Gillanders, Elizabeth M.4 aut |
700 | 1 | a Goldstein, Alisa M.4 aut |
700 | 1 | a Gruis, Nelleke A.4 aut |
700 | 1 | a Hansson, Johanu Karolinska Institutet4 aut |
700 | 1 | a Helsing, Per4 aut |
700 | 1 | a Hocevar, Marko4 aut |
700 | 1 | a Hoiom, Veronicau Karolinska Institutet4 aut |
700 | 1 | a Hopper, John L.4 aut |
700 | 1 | a Ingvar, Christianu Lund University,Lunds universitet,Kirurgi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Surgery (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)kir-cin |
700 | 1 | a Janssen, Marjolein4 aut |
700 | 1 | a Jenkins, Mark A.4 aut |
700 | 1 | a Kanetsky, Peter A.4 aut |
700 | 1 | a Kiemeney, Lambertus A.4 aut |
700 | 1 | a Lang, Julie4 aut |
700 | 1 | a Lathrop, G. Mark4 aut |
700 | 1 | a Leachman, Sancy4 aut |
700 | 1 | a Lee, Jeffrey E.4 aut |
700 | 1 | a Lubinski, Jan4 aut |
700 | 1 | a Mackie, Rona M.4 aut |
700 | 1 | a Mann, Graham J.4 aut |
700 | 1 | a Martin, Nicholas G.4 aut |
700 | 1 | a Mayordomo, Jose I.4 aut |
700 | 1 | a Molven, Anders4 aut |
700 | 1 | a Mulder, Suzanne4 aut |
700 | 1 | a Nagore, Eduardo4 aut |
700 | 1 | a Novakovic, Srdjan4 aut |
700 | 1 | a Okamoto, Ichiro4 aut |
700 | 1 | a Olafsson, Jon H.4 aut |
700 | 1 | a Olsson, Håkanu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine4 aut0 (Swepub:lu)onk-hol |
700 | 1 | a Pehamberger, Hubert4 aut |
700 | 1 | a Peris, Ketty4 aut |
700 | 1 | a Grasa, Maria Pilar4 aut |
700 | 1 | a Planelles, Dolores4 aut |
700 | 1 | a Puig, Susana4 aut |
700 | 1 | a Puig-Butille, Joan Anton4 aut |
700 | 1 | a Randerson-Moor, Juliette4 aut |
700 | 1 | a Requena, Celia4 aut |
700 | 1 | a Rivoltini, Licia4 aut |
700 | 1 | a Rodolfo, Monica4 aut |
700 | 1 | a Santinami, Mario4 aut |
700 | 1 | a Sigurgeirsson, Bardur4 aut |
700 | 1 | a Snowden, Helen4 aut |
700 | 1 | a Song, Fengju4 aut |
700 | 1 | a Sulem, Patrick4 aut |
700 | 1 | a Thorisdottir, Kristin4 aut |
700 | 1 | a Tuominen, Raineru Karolinska Institutet4 aut |
700 | 1 | a Van Belle, Patricia4 aut |
700 | 1 | a van der Stoep, Nienke4 aut |
700 | 1 | a van Rossum, Michelle M.4 aut |
700 | 1 | a Wei, Qingyi4 aut |
700 | 1 | a Wendt, Judith4 aut |
700 | 1 | a Zelenika, Diana4 aut |
700 | 1 | a Zhang, Mingfeng4 aut |
700 | 1 | a Landi, Maria Teresa4 aut |
700 | 1 | a Thorleifsson, Gudrnar4 aut |
700 | 1 | a Bishop, D. Timothy4 aut |
700 | 1 | a Amos, Christopher I.4 aut |
700 | 1 | a Hayward, Nicholas K.4 aut |
700 | 1 | a Stefansson, Kari4 aut |
700 | 1 | a Bishop, Julia A. Newton4 aut |
700 | 1 | a Barrett, Jennifer H.4 aut |
710 | 2 | a Karolinska Institutetb Kirurgi, Lund4 org |
773 | 0 | t Nature Geneticsd : Springer Science and Business Media LLCg 45:4, s. 428-432q 45:4<428-432x 1546-1718x 1061-4036 |
856 | 4 | u http://dx.doi.org/10.1038/ng.2571y FULLTEXT |
856 | 4 | u https://europepmc.org/articles/pmc3640814?pdf=render |
856 | 4 8 | u https://lup.lub.lu.se/record/3748993 |
856 | 4 8 | u https://doi.org/10.1038/ng.2571 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:126492457 |
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