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  • Eriksson Linsmeier, CeciliaLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups (author)

Soft tissue reactions evoked by implanted gallium phosphide.

  • Article/chapterEnglish2008

Publisher, publication year, extent ...

  • Elsevier BV,2008

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  • LIBRIS-ID:oai:lup.lub.lu.se:ff3a820d-0a61-443d-9b4b-37fe479cf24f
  • https://lup.lub.lu.se/record/1242887URI
  • https://doi.org/10.1016/j.biomaterials.2008.08.028DOI

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  • Language:English
  • Summary in:English

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  • Subject category:art swepub-publicationtype
  • Subject category:ref swepub-contenttype

Notes

  • Neural devices may play an important role in the diagnosis and therapy of several clinical conditions, such as stroke, trauma or neurodegenerative disorders, by facilitating motor and pain control. Such interfaces, chronically implanted in the CNS, need to be biocompatible and have the ability to stimulate and record nerve signals. However, neural devices of today are not fully optimized. Nanostructured surfaces may improve electrical properties and lower evoked tissue responses. Vertical gallium phosphide (GaP) nanowires epitaxially grown from a GaP surface is one way of creating nanostructured electrodes. Thus, we chose to study the soft tissue reactions evoked by GaP surfaces. GaP and the control material titanium (Ti) were implanted in the rat abdominal wall for evaluation of tissue reactions after 1, 6, or 12 weeks. The foreign-body response was evaluated by measuring the reactive capsule thickness and by quantification of ED1-positive macrophages and total cells in the capsule. Furthermore, the concentration of Ga was measured in blood, brain, liver and kidneys. Statistically significant differences were noticed between GaP and Ti at 12 weeks for total and ED1-positive cell densities in the capsule. The chemical analysis showed that the concentration of Ga in brain, liver and kidneys increased during 12 weeks of implantation, indicating loss of Ga from the implant. Taken together, our results show that the biocompatible properties of GaP are worse than those of the well-documented biomaterial Ti.

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  • Wallman, LarsLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups(Swepub:lu)elma-lwa (author)
  • Faxius, LindaLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Neurofysiologi,Forskargrupper vid Lunds universitet,Department of Experimental Medical Science,Faculty of Medicine,Neurophysiology,Lund University Research Groups(Swepub:lu)exp-lfa (author)
  • Schouenborg, JensLund University,Lunds universitet,Neurofysiologi,Forskargrupper vid Lunds universitet,Neurophysiology,Lund University Research Groups(Swepub:lu)mphy-jsc (author)
  • Bjursten, Lars MagnusLund University,Lunds universitet,Institutionen för experimentell medicinsk vetenskap,Medicinska fakulteten,Department of Experimental Medical Science,Faculty of Medicine(Swepub:lu)exp-lbj (author)
  • Danielsen, NilsLund University,Lunds universitet,Neurala gränsytor,Forskargrupper vid Lunds universitet,Neural Interfaces,Lund University Research Groups(Swepub:lu)mphy-nda (author)
  • NeurofysiologiForskargrupper vid Lunds universitet (creator_code:org_t)

Related titles

  • In:Biomaterials: Elsevier BV29:35, s. 4598-46041878-59050142-9612

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